The relative toxicity of DNA precursors labeled with iodine-125, iodine-131, or hydrogen-3 was studied in exponentially growing Chinese hamster cells. Per decay, iodine-125 was found to be approximately 12 times as lethal as iodine-131 and 16 times as lethal as hydrogen-3. Chromosomal aberrations induced in these cells by the three radionuclides occurred with the same relative efficacy as their lethal effects.
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