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The long-lasting impact of high-intensity training via collaborative care in patients with schizophrenia: A 5-year follow-up study.
Schizophr Res
January 2025
Faculty of Health Sciences and Social Care, Molde University College, Molde, Norway; Department of Psychosis and Rehabilitation, Psychiatry Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address:
Unlabelled: Although exercise is medicine for outpatients with schizophrenia, it is unclear if one-year adherence-supported exercise leads to a "tipping point", at which the exercise becomes a routine manifested as life-long training in the patient group.
Methods: Forty-eight outpatients (28 men/20 women: 35 ± 11 (mean ± SD) years) with schizophrenia (ICD-10: F20-29) were randomised to: 1) collaborative care group (TG), performing aerobic interval (AIT; 4 × 4-min treadmill walking/running at ∼90 % peak heart rate) and leg press maximal strength training (MST; 4 × 4 repetitions at ∼90 % maximal strength [1RM]) 2d·wk. for 1-year, supported by transportation and training supervision; or 2) control group (CG).
Timing Matters: Late, but Not Early, Exercise Training Ameliorates MASLD in Part by Modulating the Gut-Liver Axis in Mice.
J Pineal Res
December 2024
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects two billion people worldwide and is currently mostly treatable via lifestyle interventions, such as exercise training. However, it is unclear whether the positive effects of exercise are restricted to unique circadian windows. We therefore aimed to study whether the timing of exercise training differentially modulates MASLD development.
View Article and Find Full Text PDFAerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a-Sirt6 axis.
J Sport Health Sci
November 2024
Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, China; National Clinical Research Center for Metabolic Diseases, Ministry of Education, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. Electronic address:
Background: Statins are the cornerstone of low-density lipoprotein cholesterol (LDL-C)-lowering therapy; however, the therapeutic efficacy of statins in countering atherosclerotic cardiovascular disease (ASCVD) is compromised by the concurrent elevation of proprotein convertase subtilisin/kexin type 9 (PCSK9), a pivotal molecule that increases LDL-C levels. Aerobic exercise lowers PCSK9 levels, but the underlying mechanism remains unclear. Therefore, we investigated how aerobic exercise can ameliorate statin-induced increases in PCSK9 levels.
View Article and Find Full Text PDFCorrelation of exercise blood pressure levels with concomitant cardiovascular disease.
Medicine (Baltimore)
October 2024
Zhejiang Cardiovascular and Cerebrovascular Prevention Research Center, Hangzhou, China.
Hypertension is a fatal but preventable risk factor for cardiovascular disease and an important cause of death from cardiovascular disease. Exercise training has a definite clinical effect on blood pressure control. However, inappropriate exercise is ineffective and may also cause disease.
View Article and Find Full Text PDFSubacute Effects of Moderate-Intensity Aerobic Exercise in the Fasted State on Cell Metabolism and Signaling in Sedentary Rats.
Nutrients
October 2024
Laboratório de Inflamação, Metabolismo e Exercício (LAPIMEX) e Laboratório de Fisiologia Celular, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil.
Article Synopsis
- Physical inactivity leads to insulin resistance and metabolic issues even before significant weight gain occurs.
- Exercise performed while fasting can enhance metabolic benefits compared to exercising after eating.
- In a study with animals, exercising while fasting resulted in lower plasma cholesterol and improved fat metabolism in brown adipose tissue, showing potential advantages of fasted exercise.
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