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Cemdomespib Therapy Slows the Progression of Neuromuscular Weakness and Demyelination in the R75W-Connexin 32 Animal Model of Charcot-Marie-Tooth 1X Disease.
ACS Pharmacol Transl Sci
January 2025
Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, United States.
Mutations in connexin 32 (Cx32) are a common cause of Charcot-Marie-Tooth 1X (CMT1X) disease, an inherited peripheral neuropathy characterized by progressive neuromuscular weakness and demyelination. There are no approved pharmacologic therapies for CMT1X, and identifying new treatments that slow the onset and severity of neuromuscular decline may aid disease management. Cemdomespib is an orally bioavailable small molecule that improved demyelination and neuromuscular junction (NMJ) morphology in mice lacking Cx32 expression.
View Article and Find Full Text PDFA Quasi-experimental Study of Optimized Retractor Management on the Incidence of Femoral Nerve Injury Following Gynecological Surgery.
Cureus
December 2024
Anesthesiology, Jikei University School of Medicine, Tokyo, JPN.
Background Femoral neuropathy is a significant postoperative complication in gynecological surgery that can severely impact patient mobility and quality of life. Among various mechanisms of nerve injury, retractor-induced compression against the pelvic sidewall has been identified as a particularly crucial causative factor. Despite this well-recognized mechanism and its clinical importance, few studies have investigated specific preventive strategies for this iatrogenic complication.
View Article and Find Full Text PDFTreatment of unstable pelvic fractures with double INFIX.
BMC Musculoskelet Disord
January 2025
Department of Orthopaedics & Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, China.
Background: This study investigated the clinical efficacy of Double INFIX for the treatment of unstable pelvic fractures.
Methods: We performed a retrospective analysis of 23 patients with unstable pelvic fractures treated using the Double INFIX minimally invasive technique. The cohort included five cases of Tile B1 type, eight cases of B2 type, six cases of B3 type, three cases of C1 type and one case of type C2.
Meralgia paresthetica treated with temporary peripheral nerve stimulation.
Curr J Neurol
April 2024
Department of Anesthesia and Pain Management, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Efficacy of Clinical Tests in the Diagnosis of Meralgia Paresthetica: A Case Control Study.
Case Rep Med
December 2024
Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, India.
Article Synopsis
- Meralgia paresthetica (MP) is a common condition that causes tingling and discomfort in the front and outer thigh, and it can be diagnosed using tests like the pelvic compression test, neurodynamic testing, and Tinel's sign.
- A study was conducted with 30 patients who had MP to evaluate the accuracy of these diagnostic tests over a 6-month period.
- The results showed high sensitivity and specificity for all three tests, confirming that they are effective tools for diagnosing MP, especially when other potential conditions are being considered.
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