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Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma.
J Transl Med
December 2024
Tongji Medical College, Maternal and Child Health Hospital of Hubei Province, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430070, China.
Background: As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal. Previous studies have shown that tumor progression is closely related with tumor metabolism and microenvironment reshaping, with disruptions in energy metabolism playing a critical role in this process. To delve deeper into the understanding of CSCC development, our research focused on analyzing the tumor microenvironment and metabolic characteristics across different regions of tumor tissue.
View Article and Find Full Text PDFUnderstanding pathways for effective interprofessional education: a thematic analysis of medical and nursing students' insights.
BMC Med Educ
December 2024
School of Medicine, University of Debrecen, Debrecen, Hungary.
Background: As the healthcare field is undergoing a paradigm shift, the role of interprofessional education (IPE) is being widely accepted and recognized. Despite this, IPE interventions are not employed globally and the use of such interventions is variable. Additionally, there is an ongoing debate over how and when to employ IPE interventions.
View Article and Find Full Text PDFInferring transcriptomic dynamics implicated in odor fatty acid accumulation in adipose tissue of Hulun Buir sheep from birth to market.
BMC Genomics
December 2024
CAS Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China.
This study aimed to investigate the temporal accumulation of odor fatty acids (OFAs) in the dorsal subcutaneous adipose tissue, and uncover their dynamic regulatory metabolic pathways from the transcriptomic perspective in lambs from birth to market. Thirty-two Hulun Buir lambs were selected and randomly assigned to four different sampling stages following their growth trajectories: neonatal (day 1), weaning (day 75), mid-fattening (day 150), and late-fattening (day 180) stages. Results indicated that the contents of three OFAs increased progressively as lambs matured, with the most drastic change occurred at mid-fattening vs.
View Article and Find Full Text PDF[Delphi-Study: Evaluation of the new job profile "Chief Digital Officer" in German hospitals].
Z Evid Fortbild Qual Gesundhwes
December 2024
Purpose:Health e.V. Dortmund, Deutschland, APOLLON Hochschule der Gesundheitswirtschaft GmbH, Bremen, Deutschland. Electronic address:
Introduction: The main objective of the present study was to analyze the new job profile "Chief Digital Officer (CDO) in German hospitals". Here, best practices for the introduction of the job profile should be determined and the need for a CDO position to execute the digital transformation should be evaluated.
Methods: A standardized three-stage online Delphi process (expert consensus finding) followed by a roundtable discussion was performed, including 16 experts.
Scoping review of social workers' professional roles in primary care.
BMJ Open
December 2024
Department of Family Medicine, Western University Schulich School of Medicine and Dentistry, London, London, Canada.
Objectives: Maximising social workers' contributions to primary care requires clarity about their scope of practice in this context. This scoping review sought to clarify what is known about social work's scope of practice in primary care settings.
Design: A scoping review design guided by the five-stage scoping review framework developed by Arksey and O'Malley and the updated JBI Manual for Evidence Synthesis.
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