Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archopht.1968.03850040528005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of HCN channel blockade on the intensity‑response function of electroretinographic ON and OFF responses in dark adapted frogs.
Acta Neurobiol Exp (Wars)
June 2021
Department of Physiology, Medical University of Sofia, Bulgaria.
Hyperpolarization‑activated and cyclic nucleotide‑gated (HCN) channels are well expressed in the vertebrate retina. Their role in formation of electroretinographic (ERG) responses to stimulus onset (b‑wave) and stimulus offset (d‑wave) are largely unknown. In this study we investigated the effects of pharmacological blockade of HCN channels (with ZD7288 or ivabradine) on the ERG b‑ and d‑waves in dark adapted frog eyecup preparations.
View Article and Find Full Text PDFEffects of picrotoxin on light adapted frog electroretinogram are not due entirely to its action in proximal retina.
Vision Res
August 2014
Department of Physiology, Medical Faculty, Medical University, 1431 Sofia, Bulgaria. Electronic address:
In order to evaluate the site of action of picrotoxin (antagonist of ionotropic GABA receptors) on the electroretinographic (ERG) b- and d-waves, in this study we compared its effects on the intensity-response function of the ERG waves in intact light adapted frog eyecup preparations with its effects in eyecups, where the activity of proximal neurons was blocked by 1 mMN-methyl-d-aspartate (MNDA). Picrotoxin markedly enhanced the b- and d-wave amplitude and slowed the time course of the responses at all stimulus intensities in the intact eyecups. Perfusion with NMDA alone caused significant enhancement of the b-wave amplitude and diminution of the d-wave amplitude without altering their time course in the entire intensity range.
View Article and Find Full Text PDFElectroretinographic assessment of retinal function during acute exposure to normobaric hypoxia.
Graefes Arch Clin Exp Ophthalmol
January 2014
Centre for Ophthalmology, University of Tübingen, Schleichstr. 12-16, 72076, Tübingen, Germany.
Background: The current study aimed to investigate retinal function during exposure to normobaric hypoxia.
Methods: Standard Ganzfeld ERG equipment (Diagnosys LLC, Cambridge, UK) using an extended ISCEV protocol was applied to explore intensity-response relationship in dark- and light- adapted conditions in 13 healthy volunteers (mean age 25 ± 3 years). Baseline examinations were performed under atmospheric air conditions at 341 meters above sea level (FIO2 of 21 %), and were compared to hypoxia (FIO2 of 13.
Effects of dopamine receptor blockade on the intensity-response function of electroretinographic b- and d-waves in light-adapted eyes.
J Neural Transm (Vienna)
October 2014
Department of Physiology, Medical Faculty, Medical University, 1431, Sofia, Bulgaria,
The effects of dopamine receptor blockade by sulpiride (D2-class antagonist) and sulpiride plus SCH 23390 (D1-class antagonist) on the V - log I function of the electroretinographic (ERG) b- and d-waves were investigated in light-adapted frog eyes. Sulpiride significantly decreased the absolute sensitivity of the b- and d-waves. The amplitude of the both waves was diminished over the whole intensity range studied.
View Article and Find Full Text PDFParticipation of the histamine receptor encoded by the gene hclB (HCLB) in visual sensitivity control: an electroretinographic study in Drosophila melanogaster.
Mol Vis
January 2013
Department of Physiology, Medical University, Sofia, Bulgaria.
Purpose: Histaminergic transmission in the first synapse of the visual system in Drosophila melanogaster is mediated by two types of histamine receptors: 1) encoded by the gene hclA (HCLA), which is expressed in the second-order neurons-the large monopolar cells of the lamina, and is absolutely required for forward signal transmission; and 2) encoded by the gene hclB (HCLB), which is expressed in epithelial glia, and is involved in modulation of synaptic transmission from photoreceptors to large monopolar cells. The aim of our study was to establish whether the HCLB receptor-mediated modulation of synaptic transmission 1) contributes to the process of light adaptation, and 2) is involved in the control of the dynamics of sensitivity recovery after short-term light adaptation.
Methods: The effects of mutations in the gene hclB, encoding the subunits of the histamine receptor HCLB, were studied on 1) the intensity-response (V/logI) function of electroretinographic (ERG) responses under dark adaptation, as well as under three levels of background illumination; and 2) the dynamics of the dark sensitivity recovery after short-term light adaptation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!