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ADAR Therapeutics as a New Tool for Personalized Medicine.
Genes (Basel)
January 2025
Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
In the field of RNA therapy, innovative approaches based on adenosine deaminases acting on RNA (ADAR)-mediated site-directed RNA editing (SDRE) have been established, providing an exciting opportunity for RNA therapeutics. ADAR1 and ADAR2 enzymes are accountable for the predominant form of RNA editing in humans, which involves the hydrolytic deamination of adenosine (A) to inosine (I). This inosine is subsequently interpreted as guanosine (G) by the translational and splicing machinery because of their structural similarity.
View Article and Find Full Text PDFInvestigation of sensory attenuation in the somatosensory domain using EEG in a novel virtual reality paradigm.
Sci Rep
January 2025
Neurocomputation and Neuroimaging Unit (NNU), Freie Universität Berlin, Berlin, Germany.
We are not only passively immersed in a sensorial world, but we are active agents that directly produce stimulations. Understanding what is unique about sensory consequences can give valuable insight into the action-perception-cycle. Sensory attenuation is the phenomenon that self-produced stimulations are perceived as less intense compared to externally-generated ones.
View Article and Find Full Text PDFThe genetic code is not universal.
Biosystems
January 2025
The Ionian School, Early Evolution of Life Department, Genetic Code and tRNA Origin Laboratory, Via Roma 19, 67030, Alfedena, L'Aquila, Italy. Electronic address:
Recently, a new genetic code with 62 sense codons, coding for 21 amino acids, and only 2 termination codons has been identified in archaea. The authors argue that the appearance of this variant of the genetic code is due to the relatively recent and complete recoding of all UAG stop codons to codons encoding for pyrrolysine. I re-evaluate this discovery by presenting arguments that favour the early, i.
View Article and Find Full Text PDFAutomated method of bronchus and artery dimension measurement in an adult bronchiectasis population.
ERJ Open Res
November 2024
Erasmus MC, University Medical Center Rotterdam, Department of Radiology and Nuclear Medicine, Rotterdam, The Netherlands.
Aim: Bronchiectasis (BE) is a disease defined by irreversible dilatation of the airway. Computed tomography (CT) plays an important role in the detection and quantification of BE. The aim of this study was three-fold: 1) to assess bronchus-artery (BA) dimensions using fully automated software in a cohort of BE disease patients; 2) to compare BA dimensions with semi-quantitative BEST-CT (Bronchiectasis Scoring Technique for CT) scores for BE and bronchial wall thickening; and 3) to explore the structure-function relationship between BA-method lumen dimensions and spirometry outcomes.
View Article and Find Full Text PDFTrends in Financial Affordability of Healthcare Among Tribal Women of Reproductive Age: A Cross-Sectional Study From India.
Cureus
November 2024
Community and Family Medicine, All India Institute of Medical Sciences, Mangalagiri, Guntur, IND.
Background: Universal health coverage (UHC) means that all people have access to the full range of quality health services they need, when and where they need them, without financial hardship. UHC is one of the targets of Sustainable Development Goal (SDG) 3 which India is trying to achieve with various initiatives and health programs. Tribal communities form an integral part of India's population.
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