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The role of DNA methylation in placental development and its implications for preeclampsia.
Front Cell Dev Biol
December 2024
Department of Obstetrics, Obstetrics and Gynecology Center, The First Hospital of Jilin University, Changchun, China.
Preeclampsia (PE) is a prevalent and multifaceted pregnancy disorder, characterized by high blood pressure, edema, proteinuria, and systemic organ dysfunction. It remains one of the leading causes of pregnancy complications, yet its exact origins and pathophysiological mechanisms are not fully understood. Currently, the only definitive treatment is delivery, often requiring preterm termination of pregnancy, which increases neonatal and maternal morbidity and mortality rates, particularly in severe cases.
View Article and Find Full Text PDFTwin Anemia-Polycythemia Sequence With Spontaneous Resolution in Dichorionic Diamniotic Twin Pregnancy: A Case Report and a Review of the Literature.
Cureus
November 2024
Obstetrics and Gynecology, Kitasato University School of Medicine, Sagamihara, JPN.
Complications of twin pregnancy such as twin anemia-polycythemia sequence (TAPS), which involve placental anastomotic vessels, occur mostly in monochorionic diamniotic twins and they have rarely been reported in dichorionic diamniotic (DD) twins. Here, we report a case of DD twins diagnosed with TAPS with fetal hydrops caused by fetal anemia at 28 weeks, which resolved spontaneously during pregnancy. A 37-year-old pregnant woman was referred to our hospital because of a twin pregnancy at 13 weeks.
View Article and Find Full Text PDFMaternal Risk Conditions and Outcomes by Levels of Maternal Care.
J Womens Health (Larchmt)
January 2025
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina, USA.
Article Synopsis
- * Using data from the National Inpatient Sample (2017-2019), the researchers focused on maternal risk factors like severe preeclampsia, placenta accreta spectrum, and cardiac issues, and examined outcomes such as serious complications and organ failures.
- * Findings indicated that risk factors were associated with worse outcomes but that these associations were less severe in higher-level care facilities (Level III/IV), suggesting that better care settings could improve maternal health results.
Ultrasonographic placental edematous changes as predictive markers of unplanned preterm birth in post-Fontan pregnancies: A single-center observational study.
J Obstet Gynaecol Res
December 2024
Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
Aim: Fontan surgery is a palliative procedure commonly performed for functional single-ventricle heart diseases. Fontan circulation is characterized by elevated central venous pressure and low cardiac output. It causes placental hypoxia, which could lead to poor obstetric outcomes.
View Article and Find Full Text PDFGenetic characteristics and pathogenicity of variant porcine parvovirus 1 in northern China.
Vet Microbiol
November 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China. Electronic address:
Porcine parvovirus type 1 (PPV1) can lead to reproductive disorders in pregnant sows, including stillbirth, mummification, embryonic death, and infertility (SMEDI syndrome). In this study, we isolated and identified 10 PPV1 strains in northern China, with genomes around 5 kb long and minor deletions in the 127-nt repeat region. The sequence analysis results showed that compared with strain NADL-2 (Reference strain), eight amino acid substitutions on the NS1 protein and fourteen amino acid substitutions on the VP2 protein were found in the ten isolates.
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