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A Post Hoc Analysis of Older Patients with Metastatic Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Plus Bevacizumab: The Randomized Obelics Study.
Drugs Aging
March 2025
Experimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Via Mariano Semmola, 53, 80131, Naples, Italy.
Background: Phase II trials and subgroup analyses of clinical studies suggest that bevacizumab plus an oxaliplatin-based chemotherapy doublet is effective and tolerable in fit older patients with metastatic colorectal cancer (mCRC).
Objective: To evaluate the influence of age on the incidence of side effects and efficacy of this combination in patients with mCRC randomized in the prospective phase III OBELICS study.
Methods: In total, 230 patients with Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 out of 1 were retrieved on the basis of age (190 < 70 years and 40 ≥ 70 years).
Whole-body muscle MRI in patients with spinal muscular atrophy.
J Neurol
March 2025
Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Background: Spinal muscular atrophy (SMA) is a motor neuron disease with loss of musculature, which is replaced by fat. Previous magnetic resonance imaging (MRI) studies have focused on imaging muscles either in lower or upper extremities, but whole-body MRI can provide additional information on the involvement pattern. This study examined whole-body muscle fat replacement and the relationship between muscle structure, function, and bulbar symptoms.
View Article and Find Full Text PDFExplainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma.
Hepatol Int
March 2025
Department of Health Technology and Informatics, Hong Kong Polytechnic University, 11 Yuk Choi Road, Hong Kong SAR, China.
Purpose: Existing prognostic staging systems depend on expensive manual extraction by pathologists, potentially overlooking latent patterns critical for prognosis, or use black-box deep learning models, limiting clinical acceptance. This study introduces a novel deep learning-assisted paradigm that complements existing approaches by generating interpretable, multi-view risk scores to stratify prognostic risk in hepatocellular carcinoma (HCC) patients.
Methods: 510 HCC patients were enrolled in an internal dataset (SYSUCC) as training and validation cohorts to develop the Hybrid Deep Score (HDS).
Identification of DIO2 as a Molecular Therapeutic Target for Depression in Chronic Rhinosinusitis: A Comprehensive Bioinformatics and Experimental Study.
Biochem Genet
March 2025
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Rd, Wuhan, Hubei, China.
Chronic rhinosinusitis (CRS) and depression are both common conditions with significant socioeconomic impact. The high co-occurrence of depression in CRS patients suggests a common pathophysiology, but the mechanisms are unclear. This study aimed to identify potential molecular links between the two conditions.
View Article and Find Full Text PDFA multiple regression model for peak skin dose using principal component analysis in interventional radiology.
Radiol Phys Technol
March 2025
Department of Neurosurgery, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake-Cho, Miyazaki, 889-1692, Japan.
This study addresses the growing concerns of increased radiation doses to patients resulting from the increased complexity of interventional radiology procedures. Despite the importance of dose management, few facilities use dosimetry systems to measure and control patient radiation doses. To aid in patient exposure control, this research aimed to predict the peak skin dose (PSD) using dose parameters from digital imaging and communication in medicine-radiation dose structured reports.
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