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The Evolving Role of Neutrophils and Neutrophil Extracellular Traps (NETs) in Obesity and Related Diseases: Recent Insights and Advances.
Int J Mol Sci
December 2024
Department of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Obesity is a chronic, multifactorial disease characterized by persistent low-grade tissue and systemic inflammation. Fat accumulation in adipose tissue (AT) leads to stress and dysfunctional adipocytes, along with the infiltration of immune cells, which initiates and sustains inflammation. Neutrophils are the first immune cells to infiltrate AT during high-fat diet (HFD)-induced obesity.
View Article and Find Full Text PDFDevelopment of a novel latent deoxyribonucleic acid detection technique for crime scene investigation using quartz tuning fork-based biosensor technology.
Forensic Sci Int
December 2024
Biological and Environmental Sensing Research Unit, King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address:
The forensic Deoxyribonucleic Acid (DNA) fingerprinting is a tool for investigating crime scenes by identifying/tracing criminals and linking crime scenes. However, in cases where experts are unable to detect and identify any biological traces or human-derived cells at the crime scene or while testing the samples in the laboratories, all the advantages offered by forensic laboratories lose their significance. It becomes a waste of time, effort, and resources allocated to these laboratories.
View Article and Find Full Text PDFG9a/GLP Modulators: Inhibitors to Degraders.
J Med Chem
January 2025
SANKEN, Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Article Synopsis
- Histone methylation is a key part of epigenetics, involving enzymes like G9a that modify histones and regulate DNA processes such as replication and gene expression.
- Overexpression of G9a is linked to cancer development and progression, making it an appealing target for new cancer therapies.
- Research is also uncovering the role of G9a in diseases like Alzheimer's, leading to the development of G9a inhibitors that could treat various conditions by disrupting harmful signaling pathways.
Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report.
J Med Case Rep
December 2024
Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Background: Evans syndrome is a rare disorder characterized by the simultaneous or sequential combination of autoimmune hemolytic anemia and immunological thrombocytopenia, together with a positive direct antiglobulin test. This syndrome, which can be primary or secondary, is a rare initial manifestation of autoimmune diseases, notably systemic lupus erythematosus, with 1.7-2.
View Article and Find Full Text PDFMORE: a multi-omics data-driven hypergraph integration network for biomedical data classification and biomarker identification.
Brief Bioinform
November 2024
State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan, Nanjing 210023, China.
High-throughput sequencing methods have brought about a huge change in omics-based biomedical study. Integrating various omics data is possibly useful for identifying some correlations across data modalities, thus improving our understanding of the underlying biological mechanisms and complexity. Nevertheless, most existing graph-based feature extraction methods overlook the complementary information and correlations across modalities.
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