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Retinoic Acid Regulates Allergic Inflammation via Limiting Mast Cell Activation.
Food Sci Nutr
January 2025
Department of Nutrition and Food Hygiene, School of Public Health Jilin University Changchun China.
BackgroundAllergic diseases have become one of the major public health problems to be addressed in the world today. As a tissue resident cell, mast cells are crucial in the pathogenesis of allergic diseases. Vitamin A is an important fat-soluble vitamin with immunomodulatory functions.
View Article and Find Full Text PDFLncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis.
J Inflamm Res
January 2025
Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Background: Osteoarthritis (OA) is a leading cause of pain, disability, and reduced mobility worldwide, characterized by metabolic imbalances in chondrocytes, extracellular matrix (ECM), and subchondral bone. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) in OA pathogenesis. This study focuses on lncRNA PTS-1, a novel lncRNA, to explore its function and regulatory mechanisms in OA progression.
View Article and Find Full Text PDFHistomorphometric Assessment of Non-Decalcified Plastic-Embedded Specimens for Evaluation of Bone Regeneration Using Bone Substitute Materials-A Systematic Review.
Materials (Basel)
December 2024
Department of Clinical Medical Sciences, Faculty of Dental Medicine, Medical University of Varna, 9002 Varna, Bulgaria.
Article Synopsis
- The implementation of bone substitute materials has led to advancements in bone regeneration strategies, with a focus on histomorphometry for assessing bone structure.
- A systematic review analyzed 118 studies from the past decade, revealing that rats are the most commonly used animal model for research, with toluidine blue being the preferred staining method.
- Key histomorphometric parameters evaluated included new bone formation and mineral apposition rate, with calcein green favored for dynamic histomorphometry, while the review also highlighted weaknesses in current research protocols.
Anti-inflammatory effect of sea buckthorn in an HCl-induced cystitis rat model.
Investig Clin Urol
January 2025
Department of Urology, Ewha Womans University College of Medicine, Seoul, Korea.
Purpose: Although the mechanism underlying interstitial cystitis/bladder pain syndrome (IC/BPS) remains unclear, oxidative stress is suggested to be implicated in IC/BPS development. Sea buckthorn (SB; L.) contains several compounds with antioxidant properties.
View Article and Find Full Text PDFVascular and Osteological Morphology of Expanded Digit Tips Suggests Specialization in the Wandering Salamander (Aneides vagrans).
J Morphol
January 2025
Department of Biology, Gonzaga University, Spokane, Washington, USA.
For over a century researchers have marveled at the square-shaped toe tips of several species of climbing salamanders (genus Aneides), speculating about the function of large blood sinuses therein. Wandering salamanders (Aneides vagrans) have been reported to exhibit exquisite locomotor control while climbing, jumping, and gliding high (88 m) within the redwood canopy; however, a detailed investigation of their digital vascular system has yet to be conducted. Here, we describe the vascular and osteological structure of, and blood circulation through, the distal regions of the toes of A.
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