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Ectopic dopamine agonist-resistant macroprolactinoma to the clivus masquerading as a chordoma - A case report.
Endocr Regul
January 2025
1Endocrinology and Internal Medicine Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Pituitary neuroendocrine tumors (PitNETS) are common intracranial tumors, but extrasellar or ectopic PitNETS are very rare and supposed to originate from some pituitary remnants. They are mostly found in sphenoidal sinus. But particularly, ectopic clival PitNETS are highly aggressive and can cause bone invasion and can be misdiagnosed as other lesions of the skull base such as chordomas.
View Article and Find Full Text PDFGut microbiome-driven regulation of sex hormone homeostasis: a potential neuroendocrine connection.
Gut Microbes
December 2025
Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.
The gut microbiome is known to have a bidirectional relationship with sex hormone homeostasis; however, its role in mediating interactions between the primary regulatory axes of sex hormones and their productions is yet to be fully understood. We utilized both conventionally raised and gnotobiotic mouse models to investigate the regulatory role of the gut microbiome on the hypothalamic-pituitary-gonadal (HPG) axis. Male and female conventionally raised mice underwent surgical modifications as follows: (1) hormonally intact controls; (2) gonadectomized males and females; (3) gonadectomized males and females supplemented with testosterone and estrogen, respectively.
View Article and Find Full Text PDFMediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia.
BMC Psychiatry
March 2025
Department of Psychiatry, The Third Affiliated Hospital of Sun Yat- sen University, 600 Tianhe Road, Guangzhou, 510630, China.
Background: The elevated prolactin levels in first-episode drug-naïve (FEDN) schizophrenia patients may correlate with long-term stress caused by childhood trauma. This study aimed to assess the relationship between elevated prolactin levels and childhood trauma in FEDN schizophrenia patients, while also considering sex differences.
Methods: Utilizing a cross-sectional design, the study involved 88 FEDN schizophrenia patients and 76 healthy controls (HCs).
Background: Hyperprolactinemia is an endocrine disorder characterized by abnormally elevated levels of prolactin (PRL) in the serum. Macroprolactinemia refers to the condition where more than 60% of the prolactin circulating in the peripheral blood is composed of high molecular weight macroprolactins. These macroprolactins typically have low biological activity but can lead to a false increase in serum prolactin levels.
View Article and Find Full Text PDFGlucose Transport by Follicle-Stimulating Hormone Is Mediated Through the Akt/FOXO1 Pathway in Ovine Granulosa Cells.
Vet Med Sci
March 2025
College of Animal Science, Key Laboratory of Livestock and Forage Resources Utilization Around Tarim, Ministry of Agriculture and Rural Affairs, Tarim University, Alar, China.
Glycolysis in granulosa cells (GCs) is the primary location of energy metabolism and its substrates in oocytes and is closely related to follicular development in mammals. The complex morphological structure and physiological functions of GCs are regulated by follicle-stimulating hormone (FSH), but little is known about how FSH regulates glycolysis in GCs, and its mechanism remains unclear. The purpose of this study is to investigate the mechanism by which FSH activates the Akt/FOXO1 pathway, thereby regulating glucose metabolism in ovine GCs.
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