Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0002-9378(15)33749-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics.
Sci Rep
August 2018
Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky prospect, St. Petersburg, 194064, Russia.
The effects of the amide-linked (lidocaine (LDC), mepivacaine (MPV), prilocaine (PLC)) and ester-bound local anesthetics (benzocaine (BZC), procaine (PRC), and tetracaine (TTC)) on the pore-forming activity of the antifungal lipopeptide syringomycin E (SRE) in lipid bilayers were studied. Independently on electrolyte concentration in the membrane bathing solution the observed changes in conductance of SRE channels agreed with the altered membrane dipole potential under the action of ester-bound local anesthetics. Effects of aminoamides in diluted and concentrated solutions were completely different.
View Article and Find Full Text PDFThe local anesthetics procaine, lidocaine and tetracaine permit the reversible detachment of viable cells and their passaging or preservation in a non-adherent state in the absence of proteolytic enzymes. The effects of these anesthetics, dissolved in various media, on cell viability, cell detachment from substrata and preservation of cells in a non-adherent state, were compared using the AT-2 line of rat prostate carcinoma cells of moderate malignancy and the 3T3 mouse fibroblast cell line. It was found that all three local anesthetics can induce cell rounding followed by detachment of over 95% of viable cells in both lines in Ca2+/Mg(2+)-free PBS.
View Article and Find Full Text PDFMinimally invasive mitral valve surgery using single dose antegrade Custodiol cardioplegia.
Heart Lung Circ
September 2014
Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, Nedlands, Western Australia; School of Medicine, Fremantle, University of Notre Dame, Western Australia.
Objective: Our unit began a minimally invasive mitral surgery (MIMS) program utilising antegrade Custodiol solution as the sole cardioplegia. The aim of this paper is to report our results of this program.
Patients/methods: Early clinical outcomes were identified and assessed for the first consecutive 100 MIMS patients with comparisons made to a historical group operated via a sternotomy (n=113).
[The pathway of bFGF induced changes of calcium in cultured human lens epithelial cells].
Zhonghua Yan Ke Za Zhi
December 2004
Department of Ophthalmology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Objective: To investigate the pathway of basic fibroblast growth factor (bFGF) induced changes of calcium in a human lens epithelial cell line LEC-B3.
Methods: The 3rd passage of LEC-B3 cells was used in the present studies. bFGF (10 microg/L), caffeine (10 mmol/L), ryanodine (10 mmol/L), procaine (50 mmol/L) and genistein (0.
Transplacental passage of Pt after treatment with the new triamine complex cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N4]-chloride platinum (II) monohydrochloride monohydrate.
Arch Toxicol
October 2004
Istituto Nazionale per la Ricerca sul Cancro, Servizio Modelli Animali, Lgo R. Benzi, 10, 16132, Genova, Italy.
Cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N4]-chloride platinum (II) monohydrochloride monohydrate (DPR) is a monofunctional Pt triamine complex synthesized starting from cisplatin and procaine hydrochloride, characterized by a good antitumor activity coupled with low toxic effects and able to impair prenatal development of mice but at doses outside or just in the upper range of therapeutic doses. In the present paper the transplacental passage of DPR-derived Pt was investigated in CD1 mice on days 9, 13, 16 and 18 of pregnancy, 24 h after ip administration of 21 mg/kg DPR. For comparison, groups of mice were treated with an equivalent Pt-containing dose of cisplatin (10.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!