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AltitudeOmics: effect of reduced barometric pressure on detection of intrapulmonary shunt, pulmonary gas exchange efficiency, and total pulmonary resistance.
J Appl Physiol (1985)
May 2018
Department of Kinesiology, Recreation, and Sport, Indiana State University, Terre Haute, Indiana.
Blood flow through intrapulmonary arteriovenous anastomoses (Q) occurs in healthy humans at rest and during exercise when breathing hypoxic gas mixtures at sea level and may be a source of right-to-left shunt. However, at high altitudes, Q is reduced compared with sea level, as detected using transthoracic saline contrast echocardiography (TTSCE). It remains unknown whether the reduction in Q (i.
View Article and Find Full Text PDFWe investigated changes of alveolar stability and phospholipids in the pulmonary surfactant in case of acute pancreatitis induced in rats. Alveolar stability was examined by recording the pressure-volume relationship. The lung volumes during deflation decreased significantly at equivalent transpulmonary pressures, particularly when the pressure was lower than 6 cm H2O.
View Article and Find Full Text PDFThe effect of subcutaneous 1000 IU/kg calcic heparin every 12 hr for 7 days on lung lipids and pulmonary surfactant was examined in 10 male rabbits weighing 2.5-3.5 kg.
View Article and Find Full Text PDFIn 21 premature fetal goats ventilated at low tidal volumes, measurements were made of alveolar surfactant activity by bubble stability tests on alveolar liquid, lung epithelium solute permeability using radiolabeled tracer molecules, lung liquid absorption from wet and dry lung weights, effectiveness of lung gas exchange, and lung mechanics. Arterial pO2 and residual gas volume were higher and arterial pCO2 and specific compliance were lower in animals whose bubble stability test was greater than 1:5 on alveolar liquid aspirated following one hr of ventilation. Animals without detectable surfactant in fetal lung liquid before ventilation had transfer of all size tracer solutes between alveolar liquid and blood, whereas those with detectable surfactant did not allow tracers 14 A or larger in radius to cross the lung epithelium.
View Article and Find Full Text PDFMaterials which inhibit the formation of stable alveolar lining layer by lung surfactant were investigated with the pig lung homogenate. The inhibitory activity was assessed by the bubble stability test on the bubbles formed by mechanical agitation of a mixture of surface active fraction from lung homogenate and inhibitory materials. The most active inhibitory material was identified as free cholesterol.
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