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Fully Inkjet-Printed Flexible Graphene-Prussian Blue Platform for Electrochemical Biosensing.
Biosensors (Basel)
January 2025
University of Zagreb, Faculty of Chemical Engineering & Technology, Trg Marka Marulića 19, 10000 Zagreb, Croatia.
Prussian Blue (PB) is commonly incorporated into screen-printed enzymatic devices since it enables the determination of the enzymatically produced hydrogen peroxide at low potentials. Inkjet printing is gaining popularity in the development of electrochemical sensors as a substitute for screen printing. This work presents a fully inkjet-printed graphene-Prussian Blue platform, which can be paired with oxidase enzymes to prepare a biosensor of choice.
View Article and Find Full Text PDFEnabling tumor-specific drug delivery by targeting the Warburg effect of cancer.
Cell Rep Med
January 2025
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address:
Metabolic reprogramming of tumor cells is an emerging hallmark of cancer. Among all the changes in cancer metabolism, increased glucose uptake and the accumulation of lactate under normoxic conditions (the "Warburg effect") is a common feature of cancer cells. In this study, we develop a lactate-responsive drug delivery platform by targeting the Warburg effect.
View Article and Find Full Text PDFEngineered as Oral Probiotics To Enhance Clearance of Blood Lactate.
ACS Synth Biol
January 2025
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.
Article Synopsis
- Elevated lactate levels are linked to serious health issues, including sepsis and mitochondrial dysfunction, and poor lactate clearance can lead to worse outcomes in these conditions.
- Current methods for managing elevated lactate are limited, but recent findings highlight the gut's role in lactate regulation, suggesting a potential link between gut bacteria and blood lactate levels.
- This study presents a promising approach using engineered probiotic spores to deliver lactate oxidase to the gut, which successfully lowers blood lactate in mice without harming gut health or immune function.
Integrated Wearable Flexible Hydrogel Patch Sensing System for the Detection of Physiological Markers.
Anal Chem
January 2025
School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Conventional wearable flexible sensing systems typically comprise three components: a flexible substrate that contacts the skin, a signal processing module, and a signal output module. These components function relatively independently, resulting in a complex system that lacks sufficient integration. Therefore, developing an integrated wearable flexible sensing system by combining the flexible substrate, the signal processing module, and the signal output module not only enhances performance and comfort, but also reduces manufacturing costs and the risk of failure.
View Article and Find Full Text PDFEngineered Biomimetic Cancer Cell Membrane Nanosystems Trigger Gas-Immunometabolic Therapy for Spinal-Metastasized Tumors.
Adv Mater
January 2025
Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Shanghai, 200032, P. R. China.
Despite great progress in enhancing tumor immunogenicity, conventional gas therapy cannot effectively reverse the tumor immunosuppressive microenvironment (TIME), limiting immunotherapy. The development of therapeutic gases that are tumor microenvironment responsive and efficiently reverse the TIME for precisely targeted tumor gas-immunometabolic therapy remains a great challenge. In this study, a novel cancer cell membrane-encapsulated pH-responsive nitric oxide (NO)-releasing biomimetic nanosystem (MP@AL) is prepared.
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