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Cellular and molecular methods to study the role of gap junctional intercellular communication in toxicology.
Toxicol In Vitro
October 1997
Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, 150, cours Albert Thomas, F-69372 Lyon, Cedex 08, France.
Gap Junctional intercellular communication (GJIC) mediates the direct transfer of low-molecular weight factors from one cell to neighbouring ones. Since such factors include cAMP, inositol triphosphates and calcium, which are important messengers of signal transduction systems, G is believed to play a pivotal role in tissue homoeostasis. Its impairment is, therefore, likely to c functional defects in multicellular organisms.
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