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The influence of serotonin on the adhesion and growth processes in primary cultures of murine and human embryo fibroblasts and L-cells was studied separately. At the moment of seeding, serotonin shortened the time of adhesion of glass surface of these from approximately 4 to 1 or 2 hours and stimulated incorporation of tritiated thymidine and cell multiplication when introduced in 2- or 6-hour cultures. Adhesion- and growth- stimulatory activities were blocked by serotonin antagonists - cyproheptadine and tipindole, demonstrating that the specific binding of bioamine with cell receptors is essential in both the cases.
View Article and Find Full Text PDF[Effect of serotonin and its antagonists on bladder detrusor function].
Farmakol Toksikol
February 1982
In anesthetized dogs, intravenous administration of serotonin causes biphasic contraction of the urinary bladder followed by relaxation. The m-antagonist of serotonin, morphine inhibits the first phase of contraction but does not affect the second phase and relaxation. The T-antagonist tipindole exerts no effect on the serotonin-induced contraction and relaxation of the detrusor.
View Article and Find Full Text PDF[Pharmacologic analysis of the mechanism of development of serotonin diarrhea in the mouse].
Farmakol Toksikol
October 1981
Diarrhea that arises in mice given serotonin intravenously is not suppressed by tipindolol, LSD-25, ciproheptadine in doses in which these drugs block the D and T serotonin-reactive structures, or is not reduced by hexonium, thereby providing no evidence in favour of the reflex nature of the effect. Diarrhea is suppressed by morphine and atropine, thus pointing to the responsibility for its origin of M-serotoninoreactive structures of intestinal parasympathetic ganglia with subsequent involvement of the postganglionic cholinergic link.
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