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Evaluation of the effect of 48 weeks of BIC/F/TAF and DRV/c/F/TAF on platelet function in the context of rapid ART start.
HIV Res Clin Pract
December 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Introduction: The BIC-T&T study aimed to determine the efficacy of bictegraviremtricitabine/tenofovir alafenamide (BIC/F/TAF) and darunavir/cobicistat/emtricitabinetenofovir alafenamide (DRV/c/F/TAF) at suppressing viral load in a two-arm, open-label, multi-centre, randomised trial under a UK test-and-treat setting. This sub-study aimed to evaluate potential off-target cardiovascular impact by examining platelet function.
Methods: Platelets were isolated by centrifugation of citrated blood from participants attending Chelsea and Westminster Hospital or St Mary's Hospital at Week 48 following enrolment.
[Intracranial mesenchymal tumors with FET::CREB fusion: a clinicopathological analysis of six cases].
Zhonghua Bing Li Xue Za Zhi
January 2025
Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou450052, China.
To investigate the clinicopathological and molecular genetic characteristics of intracranial mesenchymal tumors with FET::CREB fusion transcript. The clinical and imaging data of 6 cases of intracranial mesenchymal tumors with FET::CREB fusion from December 2018 to December 2023 were collected at the First Affiliated Hospital of Zhengzhou University. Their histological features, immunophenotype and molecular characteristics were analyzed.
View Article and Find Full Text PDFBackground: Nasal defects after skin cancer excision can often be healed by second intention in certain circumstances.
Objective: We aim to demonstrate the utility of bovine collagen xenografts in supplementing second-intention healing of a variety of nose surgical defects.
Results: Thirty-nine patients underwent Mohs micrographic surgery of the nasal tip (33%), ala (23%), dorsum (31%), sidewall (10%), and root (3%) with the application of bovine collagen xenograft.
Acne vulgaris is one of the most common skin diseases worldwide and affects a large population of patients. Post-acne scarring can pose a significant psychosocial burden on patients of all ages; therefore, treatment approaches must be both rapid-acting and effective. Microneedling is a minimally invasive technology that involves the creation of controlled tissue microinjury and subsequent induction of collagen production and tissue remodeling.
View Article and Find Full Text PDFA Case of Ossified Tissue Misdiagnosed as Amyloid Deposits by Congo Red Stain and Birefringence.
Cureus
December 2024
Pathology, Tokyo Metropolitan Tama Medical Center, Fuchu, JPN.
Pulmonary amyloidosis is diagnosed by identifying amyloid deposits using Congo red stain (CR) and birefringence under polarized light. However, collagen fibers can also produce similar staining results, complicating diagnosis. We report a case of a 55-year-old male patient with lung opacities, initially suspected to have amyloidosis based on CR positivity and green birefringence.
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