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Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or Ductal Carcinoma In Situ in Patients Diagnosed with Flat Epithelial Atypia by Core Needle Biopsy (TBCRC 034).
Ann Surg Oncol
January 2025
Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Background: Flat epithelial atypia (FEA), a rare breast proliferative lesion, is often diagnosed following core biopsy (CB) of mammographic microcalcifications. In the prospective multi-institution TBCRC 034 trial, we investigate the upgrade rate to ductal carcinoma in situ (DCIS) or invasive cancer following excision for patients diagnosed with FEA on CB.
Patients And Methods: Patients with a breast imaging reporting and data system (BI-RADS) ≤ 4 imaging abnormality and a concordant CB diagnosis of FEA were identified for excision.
Clinical Radiologic Analysis of 2964 Papillary Breast Lesions.
Breast J
January 2025
Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Street, Nangang District, Harbin, China.
Clinical management of papillary breast lesions (PBLs) remains controversial. Our objective was to analyze the independent risk factors associated with malignant PBLs. A retrospective review of clinical variables in 2964 patients with papillary lesions available for evaluation.
View Article and Find Full Text PDFEffect of needle size on outcomes of vacuum-assisted excision of breast lesions. A randomized controlled trial.
Eur J Radiol
December 2024
Department of Radiology, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Background: Utilizing a larger needle-size instead of a smaller one in vacuum-assisted excision of breast lesions might enhance the effectiveness of the method. We conducted a clinical trial to investigate the effects of needle size 7G compared to 10G regarding excision completeness and procedural efficiency.
Materials And Methods: In this prospective, single-blinded, randomized clinical trial, the patients were enrolled between November 2019 and August 2022.
Digital breast tomosynthesis system concept addressing the needs in breast cancer screening and diagnosis.
J Med Imaging (Bellingham)
January 2025
Siemens Healthineers AG, Forchheim, Germany.
Purpose: Digital breast tomosynthesis (DBT) has been introduced more than a decade ago. Studies have shown higher breast cancer detection rates and lower recall rates, and it has become an established imaging method in diagnostic settings. However, full-field digital mammography (FFDM) remains the most common imaging modality for screening in many countries, as it delivers high-resolution planar images of the breast.
View Article and Find Full Text PDFA 3D-Printable Cell Array for In Vitro Breast Cancer Modeling.
Int J Mol Sci
December 2024
Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Breast cancer is the most common cancer and the second leading cause of cancer-related death in women. In advanced stages of the disease, breast cancer can spread and metastasize to the bone, contributing to malignant progression. The roles of tissue stiffness and remodeling of the tumor microenvironment are relevant in influencing cancer progression and invasiveness, but they are still poorly understood.
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