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"IIb or not IIb" - The necessity of dissection in patients with oral squamous cell carcinoma.
J Craniomaxillofac Surg
October 2016
Department of Oral- and Maxillofacial Surgery (Head: Frank Hölzle), RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address:
The necessary extent of cervical dissection in oral squamous cell carcinoma (OSCC) is still under discussion. Due to its anatomical properties Robins level IIb has a special role in neck dissection. This study focuses on the lymph node metastatic behaviour of OSCC in level IIb and evaluates its worth of dissection.
View Article and Find Full Text PDFA study on the prognostic value of cyclins D1 and E expression levels in resectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes.
J Exp Clin Cancer Res
September 2005
Dept. of Surgical Oncology, Medical University of Lodz, Poland.
Cyclins condition the course of a cell cycle through the activation of appropriate serine-threonine kinases. Any variation in the cyclins' expression result in pathologies of the cell division, including neoplastic proliferation. Activity of the complexes of cyclins D1 and E with appropriate cyclin-dependent kinases may be inhibited by protein P21 (WAF1/CIP1) which functions as a cell growth cycle inhibitor.
View Article and Find Full Text PDFIs frozen section effective for diagnosis of unsuspected gallbladder cancer during laparoscopic cholecystectomy?
Surg Endosc
January 2002
Department of Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-Ku, Tokyo 160-0023, Japan.
Background: Although frozen section is recommended to prevent tumor dissemination following laparoscopic cholecystectomy (LC) for unsuspected gallbladder cancer, there are no reports concretely demonstrating its effectiveness and outcome.
Methods: Frozen section during LC was performed in 990 patients with gallstones. The sensitivity, specificity of frozen section, and false-negative cases were evaluated in comparison with postoperative entire cross sections.
[Reduction of FHIT gene expression in primary lung cancer].
Zhongguo Fei Ai Za Zhi
February 2002
Department of Thoracocardiac Surgery, West China Hopsital, Sichuan University (Former The First University Hospital, West China University of Medical Sciences), Chengdu, Sichuan 610041, P.R.China.
Background: To investigate the role of FHIT (fragile histidine triad) gene in oncogenesis and progression of human lung cancer.
Methods: The expression of FHIT gene was detected in 166 lung cancer samples and 37 benign pulmonary lesion tissues as control by immunohistochemistry.
Results: The positive rate of FHIT expression in lung cancer tissues was 63.
[Reduction of FHIT gene expression in primary lung cancer: relationship with the proliferation and apoptosis of tumor cell].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2001
Department of Thoracocardiac Surgery, the First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041 P. R. China.
Objective: To investigate the role of FHIT(fragile histidine triad) gene in oncogenesis and progression of human lung cancer and explore the relationship of FHIT gene expression with the proliferation and apoptosis of tumor cells.
Methods: The expression of FHIT gene and that of Ki-67 were detected in 166 lung cancer samples and 37 lung benign lesion tissues as control by immunohistochemistry, and the apoptotic level of tumor cell was detected by terminal deoxynucl neotidyl transferase mediated dUTP nick end labelling(TUNEL).
Results: (1)The expression level of FHIT gene was found to be significantly lower in lung cancer tissues than in benign lesion tissues (P<0.
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