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Prevalence and determinants of thrombocytopenia in newborn unit at Alexandria University Hospital: a three-year report including 1000 patients.
BMC Pediatr
December 2024
Alexandria University Hospital, Pediatric Department, Alexandria, Egypt.
Background: Thrombocytopenia might be the only clinical clue of diseases in neonates. Classification of thrombocytopenia according to severity, onset offset, nadir and duration might help in identification of the etiology.
Aim: This study aims to estimate the prevalence and, identify the determinants and patterns of thrombocytopenia among neonates.
ITP in pregnancy: diagnostics and therapeutics in 2024.
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematology, Massachusetts General Hospital, Boston, MA.
Thrombocytopenia will occur in 10% of pregnancies-ranging from the clinically benign to processes that can threaten both mother and fetus. Accurately identifying the specific etiology and appropriate clinical management is challenging due to the breadth of possible diagnoses and the potential of shared features among them. Further complicating diagnostic certainty is the lack of confirmatory testing for most possible pathophysiologies.
View Article and Find Full Text PDFImmune Thrombocytopenic Purpura and Maternal and Neonatal Outcomes During Pregnancy: A Systematic Review and Meta-Analysis.
Am J Reprod Immunol
November 2024
Department of Obstetrics, Central Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China.
Immune thrombocytopenic purpura (ITP) affects 1-3 out of every 10 000 pregnancies, posing significant risks to both mothers and newborns. The condition often requires careful management to prevent severe hemorrhagic events. PubMed, Embase, Scopus, and Web of Science searched for relevant literature until June 2024.
View Article and Find Full Text PDFObstetric and neonatal outcomes of immune thrombocytopenic purpura in pregnancy and the role of delta hemoglobin index: A case-control study from a tertiary center.
J Obstet Gynaecol Res
December 2024
Division of Perinatology, Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara City Hospital, University of Health Sciences, Ankara, Turkey.
Objectives: To evaluate the effect of idiopathic thrombocytopenic purpura (ITP) on pregnancies and the role of the delta hemoglobin indices in the evaluation of treatment effectiveness.
Methods: This case-control study was conducted with 23 ITP and 115 low-risk pregnancies. Obstetric outcomes (fetal growth retardation (FGR), preterm delivery) and neonatal outcomes (weights, APGAR scores, NICU admissions, thrombocytopenia) were recorded.
Immune or inherited thrombocytopenia? A population-based cohort study on children and adolescents presenting with a low platelet count.
Pediatr Blood Cancer
December 2024
Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Article Synopsis
- Thrombocytopenia, a condition characterized by low platelet counts, is frequently observed in children, with immune thrombocytopenia (ITP) being the most common cause, while various genetic disorders can also lead to this condition.
- A study involving 506 Finnish children revealed that 79.7% were diagnosed with ITP, 6.7% had inherited platelet or primary immunodeficiency disorders, and 13.6% had other causes; a platelet count of ≤12 × 10/L effectively differentiated ITP from other conditions.
- Despite genetic testing, around 50% of patients suspected to have inherited thrombocytopenia did not receive a specific diagnosis, highlighting the importance of monitoring clinical features and family
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