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Metabolomic changes in preterminal serum samples of rhesus macaques exposed to two different lethal doses of total-body gamma-radiation.
Sci Rep
October 2024
Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
Article Synopsis
- Exposure to ionizing radiation causes cellular and molecular damage, leading to tissue and organ injury, which we examined in rhesus macaques exposed to lethal doses of radiation (7.2 Gy and 7.6 Gy).
- We analyzed blood samples collected before and after exposure using advanced mass spectrometry techniques, focusing on identifying metabolic changes related to radiation exposure, especially in preterminal samples (just before death).
- Our findings revealed significant metabolic disruptions, particularly in sphingolipid metabolism, which could serve as potential biomarkers for predicting lethality in radiation exposure situations, aiding in disaster response planning.
Metabolomic Changes in Plasma of Preterminal Stage of Rhesus Nonhuman Primates Exposed to Lethal Dose of Radiation.
Metabolites
December 2023
Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Ionizing radiation exposure is known to induce molecular and cellular injury, inflicting a cascade of potentially catastrophic events leading to tissue and organ damage. Metabolomic analysis allows for the identification and quantification of small molecules downstream of genomic changes induced by radiation exposure. We aimed to characterize metabolomic changes that underscore the prefinal stage of lethally irradiated rhesus nonhuman primates (NHPs).
View Article and Find Full Text PDFAn Update on the Superior Cerebellar Artery Origin Type.
Medicina (Kaunas)
December 2023
Department 1, Division of Anatomy, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, RO-020021 Bucharest, Romania.
Article Synopsis
- - The study focuses on the anatomical variations of the superior cerebellar artery (SCA) and its origins from the basilar artery (BA), identifying specific types including absent, preterminal, collateral, and connections from the posterior cerebral artery (PCA).
- - A total of 205 angiographic records were analyzed, revealing that the majority of SCAs originate as type 1 (71.29%), with various bilateral combinations documented, the most common being types B (1 + 1) and C (1 + 2).
- - The findings indicate that there are complex variations of SCA anatomy that are not typically covered in standard anatomy lectures, suggesting the need for tailored approaches in individual cases regarding the ends of the
Case Series: "Silent" Spinal Epidural Metastases in Metastatic Castrate-Resistant Prostate Cancer.
Case Rep Oncol
November 2023
Department of Medical Oncology, Macquarie University, Sydney, NSW, Australia.
Introduction: Spinal epidural metastases (SEM) are an uncommon phenomenon and traditionally occur as a preterminal event in heavily pre-treated patients. The introduction of novel anti-androgen therapies, such as enzalutamide and abiraterone acetate, has greatly improved the survival of patients with metastatic prostate cancer but may be changing the pattern of disease.
Case Presentation: Four patients diagnosed with metastatic castrate-resistant prostate cancer (CRPC) were commenced on enzalutamide prior to chemotherapy.
Recovery of Biventricular Function After Catheter Intervention or Surgery for Neonatal Coarctation of the Aorta.
JACC Adv
May 2023
Department of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany.
Background: Critical coarctation of the aorta (CoA) is a life-threatening condition in newborns that is associated with biventricular dysfunction.
Objectives: The purpose of this study was to examine clinical outcome and echocardiographic changes in isthmus diameter and biventricular function in newborns with critical CoA treated with balloon dilation/stent placement or surgery.
Methods: This is a retrospective single-center cohort study of 26 consecutive neonates with isolated critical CoA, who underwent transcatheter intervention (balloon angioplasty/stent; n = 10) or surgical CoA-repair (n = 16) (2012-2021).
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