After forced intragastric intubation of alcohol, rats will show a greatly increased tendency to self-administer alcohol in a free-choice situation. Diazepam (Valium) dosage (5 milligrams per kilogram of body weight) during the period ow withdrawal serves to maintain undiminished such alcohol self-administration. Without such diazepam dosage the tendency to self-administer alcohol returns to control levels.
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http://dx.doi.org/10.1126/science.561997 | DOI Listing |
Sci Rep
September 2024
Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
Chronic inflammation is associated with diabetes and contributes to the development and progression of micro- and macrovascular complications. Transcutaneous vagus nerve stimulation (tVNS) has been proposed to reduce levels of circulating inflammatory cytokines in non-diabetics by activating the cholinergic anti-inflammatory pathway. We investigated the anti-inflammatory potential of tVNS as a secondary endpoint of a randomized controlled trial in people with diabetes (NCT04143269).
View Article and Find Full Text PDFTrials
October 2022
Older People's Unit, Royal United Hospital NHS Foundation Trust, Bath, UK.
Background: Bladder symptoms are common in Parkinson's disease (PD), affecting half of all individuals. These have significant impact on quality of life as well as implications for morbidity, contributing to falls and hospital admission. The treatment of bladder symptoms can be complicated by the tendency to side-effects in people with PD including cognitive impairment and gait instability with anti-muscarinics.
View Article and Find Full Text PDFClin Dermatol
June 2022
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA; U.S. Department of Veterans Affairs, Boston Health Care System, Boston, Massachusetts, USA. Electronic address:
Although consumer spending typically declines during times of crisis, some observers have noted the tendency of consumers to spend more on less costly luxury goods instead, calling it the "lipstick effect." E-commerce sales in beauty and personal care categories, compared to pre-COVID-19, saw an increase. The mass lockdowns across many states in the United States resulted in hospitals and cosmetic clinics suspending many services.
View Article and Find Full Text PDFFront Neurosci
March 2021
Department of Neuroscience, School of Medicine, University of Kentucky, Lexington, KY, United States.
Calcium imaging has gained substantial popularity as a tool to profile the activity of multiple simultaneously active cells at high spatiotemporal resolution. Among the diverse approaches to processing of Ca imaging data is an often subjective decision of how to quantify baseline fluorescence or . We examine the effect of popular determination methods on the interpretation of neuronal and astrocyte activity in a single dataset of rats trained to self-administer intravenous infusions of cocaine and compare them with an -independent wavelet ridgewalking event detection approach.
View Article and Find Full Text PDFIndian J Med Ethics
September 2018
Assistant Professor, Department of Community Medicine, ESIC Medical College and PGIMSR, KK Nagar, Chennai Tamil Nadu 600 078, India.,
Introduction: An important virtue in the medical profession is altruism, which makes a doctor serve without an excess of expectation of return.
Objectives: To assess the level of altruism and factors influencing altruism among medical students at a medical college in Chennai.
Methods: A cross-sectional study was conducted on a sample of 224 students from the first, third and fourth years.
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