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Article Synopsis
- The article presents a clinical case of a young patient with HPV-associated penile intraepithelial neoplasia (PIN), specifically the erythematous form of bowenoid papulosis.
- It highlights the issues of delayed diagnosis due to improper diagnostic approaches and a lack of awareness among doctors about cancer-related diseases.
- The piece emphasizes the significance of early detection in preventing progression to more severe conditions like squamous cell penile carcinoma, detailing the different subtypes of PIN and their varying risks of leading to cancer.
Zoon balanitis: not a distinct clinicopathological entity?
Clin Exp Dermatol
November 2024
Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.
Zoon balanitis (ZB) was originally described in the 1950s in patients with clinical features resembling erythroplasia of Queyrat, but with histology that demonstrated a plasma cell infiltrate without evidence of dysplasia. Subsequently, ZB has been extensively reported in the literature, reflecting widespread acknowledgement as an established distinct clinicopathological entity. However, its existence as such has been questioned and there have been suggestions in the literature that ZB represents either a non-specific irritant reaction pattern, or a part of the heterogenous clinicopathological complex of male genital lichen sclerosus (MGLSc).
View Article and Find Full Text PDFEfficacy of Aminolevulinic Acid Mediated Photodynamic Therapy in the Treatment of Oral Premalignant Lesions: A Systematic Review.
Asian Pac J Cancer Prev
September 2024
Department of Prosthodontics, Government Dental College, Dibrugarh, Assam, India.
Article Synopsis
- Aminolevulinic acid (ALA) is an FDA-approved photosensitizer used in photodynamic therapy (PDT) for treating oral premalignant lesions, which are precursors to cancer.
- This systematic review analyzed studies to determine the effectiveness of ALA-PDT, filtering through 64 initial studies to focus on 17 relevant ones.
- Results indicate that ALA-PDT is effective, well-tolerated, and has no major side effects, leading to significant improvements or complete remission in oral lesions.
Squamous Cell Carcinoma In Situ-The Importance of Early Diagnosis in Bowen Disease, Vulvar Intraepithelial Neoplasia, Penile Intraepithelial Neoplasia, and Erythroplasia of Queyrat.
Diagnostics (Basel)
August 2024
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Article Synopsis
- - Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, with early recognition being crucial as delayed diagnosis can lead to more aggressive forms and surgical complications.
- - Bowen's disease (BD) is an early stage of cSCC that shows specific skin features, but histopathology is essential for accurate diagnosis and treatment planning.
- - Diagnosing precancerous conditions like vulvar and penile intraepithelial neoplasia (VIN and PeIN) can be complex, often requiring multiple biopsies and utilizing techniques like immunostaining and HPV testing to guide treatment options.
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