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Optimization of the extraction methods and evaluation of the hypoglycemic effect of extracts on artificially induced diabetic mice.
Heliyon
January 2025
Department of Chemical Engineering, Bangladesh University of Engineering and Technology, Dhaka, 1000, Bangladesh.
Synthetic antidiabetic drugs are often associated with various adverse side effects, including hypoglycemia, nausea, gastrointestinal disturbances, headaches, and even liver damage. In contrast, plant-derived natural antidiabetic bioactive compounds typically exhibit lower toxicity and fewer side effects and have been reported to aid effectively in diabetes management. These plant extracts regulate diabetes by restoring pancreatic function, enhancing insulin secretion, inhibiting intestinal glucose absorption, and facilitating insulin dependent metabolism.
View Article and Find Full Text PDFStrawberry plant growth enhancement: Effects of artificial light and methyl jasmonate-salicylic acid treatments on physiology and metabolism.
Heliyon
January 2025
Department of Agronomy and Horticulture, Faculty of Agriculture, IPB University, Bogor, Indonesia.
Strawberries, known for their antioxidant properties, exhibit changes in physiology and metabolite profiles based on cultivation techniques. In Indonesia, strawberries are typically grown in highland regions, but climate change has necessitated adjustments in cultivation practices to enhance production and quality. This study investigates the adaptation of strawberry plants in lowland environments using light-emitting diodes (LEDs) and the exogenous application of methyl jasmonate (MeJA) and methyl salicylic acid (MeSA).
View Article and Find Full Text PDFGeographical variation in metabolite profiles and bioactivity of Turcz. revealed by UPLC-Q-TOF-MS-based metabolomics.
Front Plant Sci
January 2025
College of Life and Health Sciences, Anhui Science and Technology University, Fengyang, China.
Introduction: This study aims to investigate the impact of geographical origin on the metabolite composition and bioactivity of Thesium chinense Turcz. (TCT), a member of the Apiaceae family renowned for its wide range of pharmacological properties, including antioxidant, antimicrobial, and anti-inflammatory effects. In this study, we investigated the whole plants of TCT from different regions in China, aiming to explore the geographical variation of TCT.
View Article and Find Full Text PDFProtective Role of Oxycodone in Myocardial Oxidative Stress and Mitochondrial Dysfunction Induced by Ischemia-Reperfusion.
J Biochem Mol Toxicol
February 2025
Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, China.
Ischemia-reperfusion (I/R) injury is a significant clinical problem impacting the heart and other organs, such as the kidneys and liver. This study explores the protective effects of oxycodone on myocardial I/R injury and its underlying mechanisms. Using a myocardial I/R model in Sprague-Dawley (SD) rats and an oxygen-glucose deprivation/reoxygenation (OGD/R) model in H9c2 cells, we administered oxycodone and inhibited AMP-activated protein kinase (AMPK) with Compound C (C.
View Article and Find Full Text PDFC-Reactive Protein, Uric Acid, and Coronary Artery Ectasia in Patients with Coronary Artery Disease.
Med Sci Monit
January 2025
Department of Cardiology, Kocaeli City Hospital, Health Sciences University, Kocaeli, Turkey.
BACKGROUND Coronary artery ectasia (CAE) is frequently present with coronary artery disease (CAD). However, it is not clear why some patients with CAD progress to CAE while others do not. The pathogenesis of CAE is still poorly elucidated.
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