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Spatial Distribution of Brain PET Tracers by MALDI Imaging.
J Am Soc Mass Spectrom
March 2025
The Maastricht MultiModal Molecular Imaging Institute (M4i), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Evaluating tissue distribution of Positron Emission Tomography (PET) tracers during their development conventionally involves autoradiography techniques, where radioactive compounds are used for visualization and quantification in tissues during preclinical development stages. Mass Spectrometry Imaging (MSI) offers a potential alternative, providing spatial information without the need for radioactivity with a similar spatial resolution. This study aimed to optimize a MSI sample preparation protocol for assessing PET tracer candidates with a focus on two compounds: UCB-J and UCB2400.
View Article and Find Full Text PDFEffect of Customized Corneal Crosslinking on Patients With Pellucid Marginal Degeneration.
Cornea
March 2025
Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Purpose: To evaluate the effect of customized corneal crosslinking on pellucid marginal degeneration (PMD).
Methods: Twenty-eight eyes with PMD were included. Fifteen eyes were treated with customized corneal crosslinking at Helsinki University Eye Hospital.
Is beauty beyond the eye of the butterfly?
PLoS Biol
March 2025
Faculty of Biology, LMU, Munich, Germany.
The bright colors observed across the animal world are often used during mate choice. An exciting new study in PLOS Biology suggests genetic and neural mechanisms contributing to the evolution of visual mating decisions in Heliconius butterflies.
View Article and Find Full Text PDFThe impact of canine-assisted intervention on stress reduction among university students in Thailand.
PLoS One
March 2025
Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
Stress negatively impacts university students, leading to adverse outcomes. While canine-assisted intervention (CAI) has been shown to reduce self-reported stress, no studies have investigated stress levels and associated biomarkers in dogs and students simultaneously. This study examined salivary cortisol, blood pressure, and pulse rate in 122 university students experiencing self-reported moderate to high stress before an encounter with a dog (T1), immediately before meeting a dog (T2), and after spending 15 minutes interacting with a dog (T3).
View Article and Find Full Text PDFThe Perceptions of Potential Prerequisites for Artificial Intelligence in Danish General Practice: Vignette-Based Interview Study Among General Practitioners.
JMIR Med Inform
March 2025
Center for General Practice at Aalborg University, Department of Clinical Medicine, Aalborg University, Selma Lagerløfs vej 249, Aalborg, 9260 Gistrup, Denmark, 45 29807944.
Background: Artificial intelligence (AI) has been deemed revolutionary in medicine; however, no AI tools have been implemented or validated in Danish general practice. General practice in Denmark has an excellent digitization system for developing and using AI. Nevertheless, there is a lack of involvement of general practitioners (GPs) in developing AI.
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