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Anti-cystitis glandularis action exerted by glycyrrhetinic acid: bioinformatics analysis and molecular validation.
Mol Divers
January 2025
Department of Urology Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, Guangxi, China.
Cystitis glandularis (CG) is a chronic hyperplastic disorder of the bladder, and the available clinical drug therapy is insufficient currently. Glycyrrhetinic acid (GA), a bioactive compound extracted from the roots of Glycyrrhiza glabra, is found with beneficial actions, including anti-inflammatory and anti-oxidative effects. We previously reported that GA relieves CG symptoms in animal model, implying the potential application of GA to treat CG.
View Article and Find Full Text PDFResponsiveness of glycyrrhetinic acid modified liposome toward secretory phospholipase A and its growth inhibitory in Colo205 cells.
J Liposome Res
January 2025
School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, China.
This study aimed to design a novel liposome containing GA modified phosphatidylcholine lipid (GA-PC Lip) and determine its susceptibility to tumor over-expressed secretory phospholipase A (sPLA) and its anti-cancer effect compared to conventional liposomes (Convention Lip). The liposomes were characterized for size, drug loading, encapsulation efficiency, and stability. A 6-CF release assay was conducted to assess the sensitivity of the liposomes to the tumor-overexpressed secretory phospholipase A (sPLA).
View Article and Find Full Text PDFHybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the Potentialities of Resveratrol-Loaded Lipid Nanoparticles and Hydroxyapatite to Promote Alveolar Wound Healing.
Pharmaceutics
January 2025
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Article Synopsis
- Resveratrol (RSV) can aid healing after tooth extraction by reducing inflammation, but its effectiveness is limited by poor solubility.
- Researchers developed a nanocomposite by combining RSV with lipid nanoparticles in a hydrophilic matrix to improve its delivery and enhance patient recovery.
- The optimal PEG-based nanocomposites, when combined with hydroxyapatite, were found to work well as pharmaceutical powders for creating mini-tablets that can effectively release RSV into buccal tissue, promoting better healing in the surgical site.
The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential.
Pharmaceutics
December 2024
Division of Pulmonology, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.
Lung cancer remains a major global health problem because of its high cancer-related mortality rate despite advances in therapeutic approaches. Non-small cell lung cancer (NSCLC), a major subtype of lung cancer, is more amenable to surgical intervention in its early stages. However, the prognosis for advanced NSCLC remains poor, owing to limited treatment options.
View Article and Find Full Text PDFProtective effects of 18β-glycyrrhetinic acid on -induced vascular inflammatory injury in mice.
Front Vet Sci
January 2025
Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, China.
(Pm) is a widespread zoonotic pathogen with the ability to infect wild animals, livestock, and humans. Pm infection can cause haemorrhagic pneumonia, indicating that the pathogenesis involves serious vascular injury and inflammation. 18β-Glycyrrhetinic acid (GA) has cardiovascular protective and anti-inflammatory effects, but its effect on vascular injury caused by Pm infection is not clear.
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