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Serotonin Signaling in Mouse Preimplantation Development: Insights from Transcriptomic and Structural-Functional Analyses.
Int J Mol Sci
December 2024
Department of Embryology, Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia.
Serotonin (5-HT), a versatile signaling molecule, plays a variety of roles in both neurotransmission and tissue regulation. The influence of serotonin on early development was first studied in marine invertebrate embryos and has since been documented in a variety of vertebrate species, including mammals. The present study investigates the expression and functional activity of serotonin components in mouse embryos, focusing on key receptors and transporters.
View Article and Find Full Text PDFInduction of orofacial pain potentiates fibromyalgia symptoms in mice: Relevance of nociceptin system.
Life Sci
December 2024
PUCRS, Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Curso de Graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Porto Alegre, RS, Brazil; PUCRS, Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Porto Alegre, RS, Brazil. Electronic address:
Aims: Fibromyalgia patients might experience temporomandibular disorder (TMD) as a comorbidity. However, the connection between these two syndromes is not fully understood. Nociceptin (N/OFQ) and NOP receptors are implicated in both conditions, but their relevance in the comorbidity needs investigation.
View Article and Find Full Text PDFImpact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses.
Neurotox Res
October 2024
Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central nervous system. Understanding how this system interacts with the dopaminergic system could provide valuable insights into dopamine-related pathologies. This study focused on examining both motor and non-motor dopamine-related responses in 5-lipoxygenase/leukotriene-deficient mice.
View Article and Find Full Text PDFUse of phytocanabinoids in animal models of Parkinson's disease: Systematic review.
Neurotoxicology
December 2024
Department of Veterinary Medicine, Federal Rural University of Pernambuco, Brazil.
This systematic review was carried out with the aim of evaluating the use of medicinal Cannabis for the treatment of Parkinson's disease in experimental models. Furthermore, we sought to understand the main intracellular mechanisms capable of promoting the effects of phytocannabinoids on motor disorders, neurodegeneration, neuroinflammation and oxidative stress. The experimental models were developed in mice, rats and marmosets.
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