A study was made of the influence of yeast polysaccharides of definite structure and mol wt on the accumulation of anitbody forming cells (AFC) in the spleen of mice belonging to different strains. Yeast mannans Rh. rubra and Sp. species, and also glucan Aur. pullulans with all or chiefly beta-bonds between the monosaccharide units were capable of activating the cell antibody formation, this being expressed in increased AFC production in the animals with a high immune reaction to the administration of sheep red blood cells and in the intensification of the immune response in mice with a low reaction to the antigen administered. The activity of dextrans directly depended on their mol wt. Besides, there was revealed a different reaction to polysaccharides in the animals of different genotypes.
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