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Validation of biomarkers and clinical scores for the detection of uterine leiomyosarcoma: a case-control study with an update of pLMS.
BMC Cancer
January 2025
Department of Obstetrics and Gynecology, University Medicine Greifswald, Sauerbruchstr., Greifswald, 17475, Germany.
Background: The diagnosis of rare uterine leiomyosarcoma (uLMS) remains a challenge given the high incidence rates of benign uterine tumors such as leiomyoma (LM). In the last decade, several clinical scores and blood serum markers have been proposed. The aim of this study is to validate and update the pLMS clinical scoring system, evaluating the accuracy of the scoring system by Zhang et al.
View Article and Find Full Text PDFAn Unusual Diagnosis of Rectosigmoid Leiomyoma in an Adult: A Rare Case Report.
Clin Med Insights Case Rep
December 2024
Department of Gastroenterology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Leiomyomas are uncommon tumors of the gastrointestinal system, representing around 0.03% to 0.05% of all rectal tumors.
View Article and Find Full Text PDFRisk Stratification of Uterine Smooth Muscle Tumors: The Role of Morphology, Immunohistochemistry, and Molecular Testing.
Adv Anat Pathol
January 2025
Department of Pathology, University of Michigan-Michigan Medicine, Ann Arbor, MI.
Uterine smooth muscle neoplasms are a biologically and clinically heterogeneous group of tumors. Morphology is the cornerstone of pathologic diagnosis of these tumors, and most are readily classified as benign or malignant on the basis of routine histologic examination. However, rare subsets-including intravenous leiomyomatosis, benign metastasizing leiomyoma, and disseminated peritoneal leiomyomatosis-have a capacity for extrauterine spread despite benign cytomorphology.
View Article and Find Full Text PDFGenomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei.
J Pathol
December 2024
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with a benign clinical course. In contrast, leiomyosarcoma (LMS) is a high-grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM-BN and LMS show distinct morphologies, they share similar immunoprofiles and molecular alterations, with both considered 'genomically unstable'.
View Article and Find Full Text PDFUterine Smooth Muscle Tumor of Undetermined Malignant Potential (STUMP): A Diagnostic Challenge.
Cureus
November 2024
Medical Oncology, Tata Main Hospital, Jamshedpur, IND.
Article Synopsis
- Smooth muscle tumors of the uterus vary from benign leiomyomas to malignant leiomyosarcomas, with STUMP representing a challenging gray area of tumors with uncertain malignant potential.
- A case study is presented of a 52-year-old woman with severe menorrhagia, diagnosed with STUMP after a hysteroscopy and biopsy, which raised concerns about the possibility of leiomyosarcoma.
- The patient underwent a radical hysterectomy, where the final diagnosis remained STUMP, and has since been on regular follow-up without any recurrence, highlighting the rarity of STUMP presenting as a uterine polyp.
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