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Diagnostic accuracy of ultra-low-dose chest CT vs chest X-ray for acute non-traumatic pulmonary diseases.
Eur Radiol
January 2025
Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Objectives: To compare the diagnostic accuracy of ULDCT to CXR for detecting non-traumatic pulmonary diseases at the emergency department (ED) and to study diagnostic confidence levels.
Methods: Secondary analysis of the prospective OPTIMACT trial (2418 ED participants randomly allocated to ULDCT or CXR). Diagnoses at imaging at the ED were compared to the reference diagnosis on day 28.
Optimized sequential model for superior classification of plant disease.
Sci Rep
January 2025
D. Y. Patil Agriculture and Technical University, Talsande, Maharashtra, India.
Indian agriculture is vital sector in the country's economy, providing employment and sustenance to millions of farmers. However, Plant diseases are a serious risk to crop yields and farmers' livelihoods. Traditional plant disease diagnosis methods rely heavily on human expertise, which can lead to inaccuracies due to the invisible nature of early disease symptoms and the labor-intensive process, making them inefficient for large-scale agricultural management.
View Article and Find Full Text PDFIs there a mental health diagnostic crisis in primary care? Current research practices in global mental health cannot answer that question.
Epidemiol Psychiatr Sci
January 2025
Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, Center for Global Mental Health, King's College London, London, UK.
In low- and middle-income countries, fewer than 1 in 10 people with mental health conditions are estimated to be accurately diagnosed in primary care. This is despite more than 90 countries providing mental health training for primary healthcare workers in the past two decades. The lack of accurate diagnoses is a major bottleneck to reducing the global mental health treatment gap.
View Article and Find Full Text PDF[A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12].
Rinsho Shinkeigaku
January 2025
Department of Neurology, Saiseikai Yokohamashi Nanbu Hospital.
An 86-year-old male patient developed paresthesia in both hands, and six months later, pancytopenia was noted. He was diagnosed with myelodysplastic syndrome following bone marrow aspiration. Despite high serum vitamin B12 level, elevated level of serum homocysteine, positive anti-intrinsic factor antibody, and T-weighted hyperintense lesions on spinal cord MRI led to a diagnosis of subacute combined degeneration of the spinal cord.
View Article and Find Full Text PDFConfined CHA-HCR system for sensitive and specific detection of ANXA2 mRNA in adenomyosis tissues.
J Pharm Biomed Anal
January 2025
Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350005, China; FujianKey Laboratory of Women and Children's Critical Diseases Research, Fuzhou, Fujian 350005, China. Electronic address:
Isothermal, enzyme-free amplification techniques, such as the hybridization chain reaction (HCR) and catalytic hairpin assembly (CHA), have gained significant attention for mRNA analysis. Despite their potential, these methods still face challenges, including false positives and low amplification efficiency. To overcome these limitations, we have developed a confined catalytic hairpin assembly and hybridization chain reaction (CHA-HCR) system that utilizes cholesterol-modified hairpin probes to enhance the sensitivity and specificity of mRNA detection.
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