Evidence for withdrawal from caffeine by rats.

Pharmacol Biochem Behav

Published: May 1977

Injections of caffeine produced avoidance of a novel flavor. Rats which had previously received injections of caffeine on each of twelve days avoided a novel solution which had been associated with the absence of caffeine. This and other controls suggest that physiological withdrqwal from caffeine is the mechanism for this avoidance.

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http://dx.doi.org/10.1016/0091-3057(77)90116-2DOI Listing

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