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Role of IFN-γ, IL-33, and IL-35 concentrations in tuberculous pleural effusion in diagnosis and analysis of the effectiveness of combined tests.
Medicine (Baltimore)
November 2024
Pneumology Department, Baoding People's Hospital, Baoding, Hebei, China.
This study examines the diagnostic utility of the combined interleukin-33 (IL-33), interferon-γ (IFN-γ), and interleukin-35 (IL-35) test in tuberculous pleural effusion. Forty patients with pleural effusion of unknown etiology admitted to the hospital between December 2020 and December 2023 were selected as the study group. The patients were further categorized into tuberculous (TB) (n = 20) and malignant (n = 20) groups on the basis of their relevant data, while sera from 20 healthy medical checkups were used as control group.
View Article and Find Full Text PDFIL-10 mediates pleural remodeling in systemic lupus erythematosus.
Cell Commun Signal
November 2024
Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Background: Interleukin-10 (IL-10), a pivotal anti-inflammatory cytokine, has gotten attention for its involvement in tissue remodeling and organ fibrosis. Pleurisy and subsequent pleural remodeling are recognized as quantifiable indicators of systemic lupus erythematosus (SLE) activity. However, the role of IL-10 in SLE-associated pleural remodeling remains unknown.
View Article and Find Full Text PDFDiagnostic value of effusion adenosine deaminase, γ-interferon release assay and effusion lactatedehy drogenase/effusion adenosine deaminase for tuberculous pleural effusion in patients aged 60 years and above.
Front Cell Infect Microbiol
October 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Article Synopsis
- China is facing a growing population of older adults, which increases the risk of developing tuberculous pleural effusion (TPE) due to weakened immune systems with age.
- A study analyzed 519 patients aged 60 and above to determine the effectiveness of seven biomarkers in diagnosing TPE, identifying Effusion ADA, IGRA, and Effusion LDH/ADA as key differentiators between TPE and non-TPE.
- The combination of these biomarkers achieved high diagnostic accuracy for TPE in older patients, with an AUC of 0.925, sensitivity of 85.23%, and specificity of 89.57%, emphasizing the importance of multiple indicators for effective diagnosis.
High endothelial venules in the pleura: MECA-79 expression in mesothelioma, pleural metastasis and pleuritis.
Pathol Res Pract
November 2024
Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address:
Article Synopsis
- High endothelial venules (HEVs) are specialized blood vessels that help lymphocytes move from blood into tissues, and this study is the first to investigate their presence in pleural tissue associated with tumors.
- The researchers analyzed 149 surgical pleural biopsies, using immunohistochemistry to identify HEVs, finding them in 68% of the samples, with a higher occurrence in neoplastic diseases compared to non-neoplastic ones.
- The findings suggest that HEVs play a role in the immune response within pleural diseases, highlighting their significance in both inflammatory and cancer-related conditions in the pleural cavity.*
Cystatin F Depletion in -Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection.
Int J Mol Sci
July 2024
Host-Pathogen Interactions Unit, Research Institute for Medicines, iMed-ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Cystatin F (CstF) is a protease inhibitor of cysteine cathepsins, including those involved in activating the perforin/granzyme cytotoxic pathways. It is targeted at the endolysosomal pathway but can also be secreted to the extracellular milieu or endocytosed by bystander cells. CstF was shown to be significantly increased in tuberculous pleurisy, and during HIV coinfection, pleural fluids display high viral loads.
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