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Degradation kinetics of artesunate for the development of an ex-tempore intravenous injection.
Malar J
September 2022
Jimma University Laboratory of Drug Quality (JuLaDQ) and School of Pharmacy, Jimma University, PO Box 378, Jimma, Ethiopia.
Background: Artesunate is recommended by the World Health Organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria. However, artesunate is inherently unstable in an aqueous solution and hydrolyses rapidly after its preparation for injection. Therefore, the aim of the study was to evaluate the stabilizing effects of phosphate buffer and mannitol against short-term (ex-tempore) artesunate hydrolysis.
View Article and Find Full Text PDFInfluenza vaccination hesitancy in five countries of South America. Confidence, complacency and convenience as determinants of immunization rates.
PLoS One
February 2021
Sanofi Pasteur LATAM, Panama.
Introduction: Influenza morbidity and mortality are significant in the countries of South America, yet influenza vaccination is as low as 56.7% among pregnant women, reaching 76.7% of adults with chronic diseases.
View Article and Find Full Text PDFCandida metrosideri pro tempore sp. nov. and Candida ohialehuae pro tempore sp. nov., two antifungal-resistant yeasts associated with Metrosideros polymorpha flowers in Hawaii.
PLoS One
December 2020
Department of Microbial and Molecular Systems, Laboratory for Process Microbial Ecology and Bioinspirational Management, KU Leuven, Leuven, Belgium.
Flowers produce an array of nutrient-rich exudates in which microbes can thrive, making them hotspots for microbial abundance and diversity. During a diversity study of yeasts inhabiting the flowers of Metrosideros polymorpha (Myrtaceae) in the Hawai'i Volcanoes National Park (HI, USA), five isolates were found to represent two novel species. Morphological and physiological characterization, and sequence analysis of the small subunit ribosomal RNA (rRNA) genes, the D1/D2 domains of the large subunit rRNA genes, the internal transcribed spacer (ITS) regions, and the genes encoding the largest and second largest subunits of the RNA polymerase II (RPB1 and RPB2, respectively), classified both species in the family Metschnikowiaceae, and we propose the names Candida metrosideri pro tempore sp.
View Article and Find Full Text PDFGloboidnan A, rabdosiin and globoidnan B as new phenolic markers in European-sourced comfrey (Symphytum officinale L.) root samples.
Phytochem Anal
July 2021
Biothermodynamics, TUM School of Life and Food Sciences Weihenstephan, Technical University of Munich, Freising, 85354, Germany.
Introduction: Symphytum officinale L. (comfrey, Boraginaceae) is a cultivated or spontaneously growing medicinal plant that is traditionally used for the treatment of bone fractures, hematomas, muscle pains and joint pains. A wide range of topical preparations and dried roots for ex tempore applications are marketed in European drug stores or pharmacies.
View Article and Find Full Text PDFAn Aggressive Form of MALT Lymphoma of the Stomach with Pancreas Infiltration.
Med Arch
June 2016
Clinic for Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
Introduction: MALT lymphoma accounts for 7-8% of all B-cell lymphomas and at least 50% of primary gastric lymphoma, with the highest incidence at between 50 and 60 years of age. Aggressive forms are rare, as are indications for multi-visceral resection.
Case Study: A patient, 33 years old, was admitted to the tertiary hospital due to a biopsy at a small community hospital confirming adenocarcinoma of the stomach.
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