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The effect of irisin on the ultrastructure of the thoracic aorta in rat: A morphometric study.
Morphologie
September 2024
Faculty of Medicine, The University of Jordan, Amman, Jordan.
Background: One of the most recent hormones to be identified and isolated is irisin, extracted from mouse skeletal muscle in 2012. Irisin has been proven to alter blood pressure, which has an impact on blood vessels, enhance endothelial functions, and prevent injury to endothelial cells. The current study aimed to study the effect of irisin on the ultrastructure of the rat thoracic aorta using the transmission electron microscope (TEM).
View Article and Find Full Text PDFDegradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles.
Eur J Cell Biol
June 2024
Chair of Translational Cell Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany. Electronic address:
Efficient degradation of phagocytic cargo in lysosomes is crucial to maintain cellular homeostasis and defending cells against pathogens. However, the mechanisms underlying the degradation and recycling of macromolecular cargo within the phagolysosome remain incompletely understood. We previously reported that the phagolysosome containing the corpse of the polar body in C.
View Article and Find Full Text PDFA time window for rescuing dying retinal ganglion cells.
Cell Commun Signal
January 2024
University Eye Clinic Maastricht UMC+, Maastricht University Medical Center+, Maastricht, 6229 HX, The Netherlands.
Background: Retinal ganglion cell (RGC) degeneration and death cause vision loss in patients with glaucoma. Regulated cell death, once initiated, is generally considered to be an irreversible process. Recently, we showed that, by timely removing the cell death stimulus, stressed neuronal PC12 cells can recover from phosphatidylserine (PS) exposure, nuclear shrinkage, DNA damage, mitochondrial fragmentation, mitochondrial membrane potential loss, and retraction of neurites, all hallmarks of an activated cell death program.
View Article and Find Full Text PDFA cost-effective and efficient ex vivo, ex situ human whole brain perfusion protocol for immunohistochemistry.
J Neurosci Methods
April 2024
Department of Pathological Anatomy and Forensic Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia; Estonian Forensic Science Institute, Tervise 20, Tallinn, Estonia.
Background: Chemical fixation of the brain can be executed through either the immersion method or the perfusion method. Perfusion fixation allows for better preservation of the brain tissue's ultrastructure, as it provides rapid and uniform delivery of the fixative to the tissue. Still, not all facilities have the expertise to perform perfusion fixation, with initial high cost and complexity of perfusion systems as the main factors limiting its widespread usage.
View Article and Find Full Text PDFThe effect of ingested copper on the structural and cytotoxic properties of Steatoda grossa (Theridiidae) spider silk.
Zoology (Jena)
January 2024
Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia, Bankowa 9, 40-007 Katowice, Poland.
Spiders, assigned to macroconcentrators of heavy metals, are particularly threatened by the toxic effects of these chemicals. Until now, it has not been specified to what extent metals alter the processes proceeding in silk glands and if such changes could consequently influence the chemical and structural properties of the spun web threads. In the present study selected biological properties of Steatoda grossa (Theridiidae) silk yarn after nutritional exposure to copper at sublethal doses (0.
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