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Multiomics in cancer biomarker discovery and cancer subtyping.
Adv Clin Chem
January 2025
School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea; Department of Integrated Biomedical and Life Science, Korea University, Seoul, Republic of Korea; BK21FOUR R&E Center for Learning Health Systems, Korea University, Seoul, Republic of Korea; L-HOPE Program for Community-Based Total Learning Health Systems, Korea University, Seoul, Republic of Korea. Electronic address:
The advent of multiomics has ushered in a new era of cancer research characterized by integrated genomic, transcriptomic and proteomic analysis to unravel the complexities of cancer biology and facilitate the discovery of novel biomarkers. This chapter provides a comprehensive overview of the concept of multiomics, detailing the significant advances in the underlying technologies and their contributions to our understanding of cancer. It delves into the evolution of genomics and transcriptomics, breakthroughs in proteomics, and overarching progress in multiomic methodologies, highlighting their collective impact on cancer biomarker discovery.
View Article and Find Full Text PDFA study of preservice teachers' digital competence development: Exploring the role of direct instruction, integrated practice, and modeling.
Eval Program Plann
January 2025
Department of English and German Studies, Uviversitat Rovira I Virgili, Tarragona, Spain. Electronic address:
As technology rapidly transforms educational landscapes, the imperative for teachers to possess digital competence becomes increasingly vital. This paper explores the effectiveness of different approaches employed by teacher education programs in equipping preservice teachers with digital competence. The study categorizes these approaches into three main groups: direct, integrated, and modeling.
View Article and Find Full Text PDFDirect electrochemical sensing of ampicillin in aqueous media by a ruthenium oxide electrode decorated with a molecularly imprinted polymer.
Talanta
January 2025
Department of Materials and Environmental Technology, Tallinn University of Technology, Ehitajate tee 5, 19086, Tallinn, Estonia. Electronic address:
Ampicillin (AMP) ranks third among the top ten most frequently sold antibiotic combinations globally, raising concerns due to its extensive use. Improper disposal practices in agriculture, aquaculture, and healthcare have led to environmental contamination of water sources with elevated AMP levels. Current methods for detecting such contamination are costly, require sophisticated equipment, and depend on skilled personnel and unstable natural receptors.
View Article and Find Full Text PDFIs Overlain Display a Right Choice for AR Navigation? A Qualitative Study of Head-Mounted Augmented Reality Surgical Navigation on Accuracy for Large-Scale Clinical Deployment.
CNS Neurosci Ther
January 2025
Department of Neurosurgery, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital, Qiangyuan, China.
Background: During the course of the past two decades, head-mounted augmented reality surgical navigation (HMARSN) systems have been increasingly employed in a variety of surgical specialties as a result of both advancements in augmented reality-related technologies and surgeons' desires to overcome some drawbacks inherent to conventional surgical navigation systems. In the present time, most experimental HMARSN systems adopt overlain display (OD) that overlay virtual models and planned routes of surgical tools on corresponding physical tissues, organs, lesions, and so forth, in a surgical field so as to provide surgeons with an intuitive and direct view to gain better hand-eye coordination as well as avoid attention shift and loss of sight (LOS), among other benefits during procedures. Yet, its system accuracy, which is the most crucial performance indicator of any surgical navigation system, is difficult to ascertain because it is highly subjective and user-dependent.
View Article and Find Full Text PDFScoping review of robotics technology in spinal surgery with highlights of the Annual Seattle Science Foundation Course.
Ann Transl Med
December 2024
Department of Neurosurgery, Providence Neuroscience Center Everett, Everett, WA, USA.
Background: Robotic assistance has become increasingly prevalent in spinal surgery in recent years, emerging as a tool to increase accuracy and precision and lower complication rates and radiation exposure. The 7 and 8 Annual Seattle Science Foundation (SSF) Robotics Courses showcased presentations and demonstrations from some of the field's most experiences leaders on latest topics in robotics and spinal surgery, including cutting-edge preoperative planning technologies, augmented reality (AR) in the operating room, cervical fusion with transpedicular screws, and neuro-oncologic management. We provide a scoping review of the use of robotics technology in spinal surgery featuring highlights from the 7 and 8 Annual SSF Robotics Courses.
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