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Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.
Lancet Oncol
January 2025
Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
Background: Optimal therapy following breast-conserving surgery in older adults with low-risk, early-stage breast cancer remains uncertain. The EUROPA trial aims to compare the effects of radiotherapy and endocrine therapy as single-modality treatments on health-related quality of life (HRQOL) and ipsilateral breast tumour recurrence (IBTR) outcomes in this population.
Methods: This non-inferiority, phase 3, randomised study was conducted at 18 academic hospitals across Italy (17 centres) and Slovenia (one centre).
Similarities and differences in self-reported symptoms and comorbidities between hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.
Rheumatol Adv Pract
November 2024
Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Objectives: Patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) experience a wide array of symptoms and system disorders. This study aimed to identify whether differences occurred in 115 self-reported symptoms and comorbidities in patients diagnosed with hEDS or HSD.
Methods: In this study we analysed self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS, HSD or no hypermobile conditions.
Presentation and management outcome of foot drop with tibialis posterior tendon transfer.
World J Orthop
November 2024
Department of Plastic Surgery, Consultant Plastic Surgeon and Head of Plastic Surgery Department, National Institute of Rehabilitation Medicine, Islamabad 44000, Pakistan.
Article Synopsis
- Foot drop leads to significant mobility issues, including weak ankle movement and an awkward walking style, which increases energy use and risk of injury.
- This study aimed to assess foot drop patients and the effectiveness of tibialis posterior tendon transfer to improve ankle dorsiflexion over 7 years at a rehabilitation institute in Pakistan.
- Of the 37 patients studied, most were young males with road traffic accidents as the leading cause; post-surgery outcomes showed varying degrees of improvement, with complications occurring in a small number of cases.
Inhibition of GZMB activity ameliorates cognitive dysfunction by reducing demyelination in diabetic mice.
Free Radic Biol Med
November 2024
Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou, China; Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou, China. Electronic address:
Article Synopsis
- Diabetic cognitive dysfunction (DCD) is linked to oligodendrocytes and granzyme B (GZMB), which may cause axonal damage; this study investigates GZMB's role in DCD.* -
- Using a mouse model of diabetes, researchers assessed learning and memory through a water maze, while examining the effects of a GZMB inhibitor (SerpinA3N) on myelin integrity and cellular stress.* -
- Results indicated that inhibiting GZMB improved cognitive function, reduced stress in oligodendrocytes, enhanced myelin protein expression, and decreased demyelination, suggesting a therapeutic target for DCD.*
[Amaurosis fugax in Marfan syndrome with myxomatous degeneration].
Rinsho Shinkeigaku
October 2024
Department of Neurology, The Jikei University School of Medicine.
A 28-year-old male presented with a sudden, transient visual impairment in the right eye. Brain MRI revealed no obvious ischemic lesions, and he was diagnosed with amaurosis fugax. Physical examination revealed characteristic features of Marfan syndrome, along with a family history of tall stature and valvular heart disease.
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