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Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways.
Phytomedicine
December 2024
School of Biological Science and Technology, University of Jinan, Jinan, 250022, China. Electronic address:
Background: Renal fibrosis is a major pathological feature of many chronic kidney diseases, and traditional Chinese medicines (TCM) have shown promising therapeutic potential for treating renal fibrosis. Although the extracts or fractions of Morus alba leaves and twigs have been reported to ameliorate renal fibrosis, the beneficial effects of M. alba root bark (commonly known as Sang-Bai-Pi), a well-known TCM, on this disorder have not been investigated.
View Article and Find Full Text PDFSafety assessment on CBD-rich hemp extract in sub-chronic cross-sex study with rats.
Toxicol Appl Pharmacol
December 2024
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic. Electronic address:
Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L., in which there is currently growing interest for medicinal use. Here, we focused on the safety and pharmacokinetics of a CBD-rich (77 %, w/w) full-spectrum hemp extract in male and female rats.
View Article and Find Full Text PDF[Neurochemical mechanisms of tremor in Parkinson's disease].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Pirogov Russian National Research Medical University (Pirogovsky University), Moscow, Russia.
Tremor is one of the main motor symptoms of Parkinson's disease, and its pathophysiology remains largely unknown. The clinical and pathomorphological heterogeneity of tremor and the not always response to therapy complicate the task of researchers and clinicians. This review discusses the specific degeneration of neurotransmitter systems driving the development of tremor, and the influence of neurotransmitters on specific anatomical entities according to current models explaining tremor.
View Article and Find Full Text PDFThe second week corneal changes in rodents model of streptozotocin-induced diabetes.
Wiad Lek
December 2024
MUNICIPAL ENTERPRISE "CENTRAL CITY HOSPITAL OF CHERVONOGRAD CITY COUNCIL ", CHERVONOGRAD, UKRAINE.
Objective: Aim: Installation the changes of the microstructural rearrangement of the layers of the rat cornea at the end of the second week of experimental streptozotocin- induced diabetes.
Patients And Methods: Materials and Methods: The research was conducted on 15 sexually mature, outbred white male rats, weighing 120-130 g. Two groups of animals were used in the work: the first group with developing diabetes (2 weeks after administration of streptozotocin); the second group served as control and received injections of 0.
NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.
Ecotoxicol Environ Saf
December 2024
The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou 550025, PR China. Electronic address:
Environmental exposure to arsenic is associated with significant health risks, including diabetogenic effects linked to pancreatic dysfunction. The NOD-like receptor protein 3 (NLRP3) inflammasome has been implicated in various metabolic abnormalities; however, its specific role in arsenic-induced pancreatic dysfunction remains insufficiently understood. This study aimed to elucidate the involvement and underlying mechanisms of the NLRP3 inflammasome in arsenic-induced pancreatic beta cells dysfunction through in vivo and in vitro models.
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