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Analytical Validation and Performance of a Blood-Based P-tau217 Diagnostic Test for Alzheimer Disease.
J Appl Lab Med
January 2025
Eli Lilly and Company, Indianapolis, IN, United States.
Background: Blood-based biomarkers, especially P-tau217, have been gaining interest as diagnostic tools to measure Alzheimer disease (AD) pathology.
Methods: We developed a plasma P-tau217 chemiluminescent immunoassay using 4G10E2 and IBA493 as antibodies, a synthetic tau peptide as calibrator, and the Quanterix SP-X imager. Analytical validation performed in a College of American Pathologists-accredited CLIA laboratory involved multiple kit lots, operators, timepoints, and imagers.
Sociodemographic and regional differences in neonatal and infant mortality in Switzerland in 2011-2018: the Swiss National Cohort.
Swiss Med Wkly
November 2024
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Background And Aims: Despite a well-funded healthcare system with universal insurance coverage, Switzerland has one of the highest neonatal and infant mortality rates among high-income countries. Identifying avoidable risk factors targeted by evidence-based policies is a public health priority. We describe neonatal and infant mortality in Switzerland from 2011 to 2018 and explore associations with neonatal- and pregnancy-related variables, parental sociodemographic information, regional factors and socioeconomic position (SEP) using data from a long-term nationwide cohort study.
View Article and Find Full Text PDFAssessment of psychometric properties of the Persian version of the spiritual care competency self-assessment tool.
Palliat Support Care
January 2025
Department of Emergency and Critical Care Nursing, School of Nursing and Midwifery Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: Spiritual care is essential for the health and well-being of patients and their families, so nursing and midwifery students should have professional competency in this field.
Objectives: The present study aimed to translate the Spiritual Care Competency Self-Assessment Tool for nursing and midwifery students into Persian and evaluate its psychometric properties.
Methods: This study has a methodological study design.
Parameter uniform finite difference formulation with oscillation free for solving singularly perturbed delay parabolic differential equation via exponential spline.
BMC Res Notes
January 2025
Department of Mathematics, Jimma University, Jimma, Ethiopia.
Objective: In this work, singularly perturbed time dependent delay parabolic convection-diffusion problem with Dirichlet boundary conditions is considered. The solution of this problem exhibits boundary layer at the right of special domain. In this layer the solution experiences steep gradients or oscillation so that traditional numerical methods may fail to provide smooth solutions.
View Article and Find Full Text PDFOverview of Effects of Motor Learning Strategies in Neurologic and Geriatric Populations: A Systematic Mapping Review.
Arch Rehabil Res Clin Transl
December 2024
Research Centre for Nutrition, Lifestyle and Exercise, School of Physiotherapy, Zuyd University of Applied Sciences, Faculty of Health, Heerlen, The Netherlands.
Objective: To provide a broad overview of the current state of research regarding the effects of 7 commonly used motor learning strategies to improve functional tasks within older neurologic and geriatric populations.
Data Sources: PubMed, CINAHL, and Embase were searched.
Study Selection: A systematic mapping review of randomized controlled trials was conducted regarding the effectiveness of 7 motor learning strategies-errorless learning, analogy learning, observational learning, trial-and-error learning, dual-task learning, discovery learning, and movement imagery-within the geriatric and neurologic population.
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