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[TRANSFORMATION OF MYASTHENIA GRAVIS INTO AMYOTROPHIC LATERAL SCLEROSIS, OR THEIR CONCOMITANCE? (CASE REVIEW)].
Georgian Med News
March 2018
I. Javakhishvili Tbilisi State University, P. Sarajishvili Institute of Neurology, Georgia.
The authors present a case of 75-year-old male patient with typical clinical and electroneuromyographic signs of Amyotrophic Lateral Sclerosis (ALS), manifested in 4 years after a diagnosis of generalized Myasthenia Gravis (MG) had been made. The aim of the article is to assess the possibility of pathogenetic integrated comorbidity of MG and ALS, which may have resulted from a common aberrant immune process and to emphasize the importance of detailed clinical analysis and adequate diagnostic methods essential for correct diagnosis and treatment. Only several cases of coexistence of MG and ALS have been described in medical literature.
View Article and Find Full Text PDFRapidly progressive amyotrophic lateral sclerosis initially masquerading as a demyelinating neuropathy.
Neurophysiol Clin
June 2013
EA 4391, faculté de médecine de Créteil, université Paris Est Créteil, Créteil, France.
Rare cases of demyelinating neuropathy have been described in association with amyotrophic lateral sclerosis (ALS). We report two patients with typical ALS whose initial electroneuromyographic (ENMG) presentation could suggest the existence of a process of motor nerve fiber demyelination. However, subsequent ENMG examinations and the fatal course of the disease in a few months rather supported severe ongoing axonal degeneration at the origin of motor nerve conduction abnormalities.
View Article and Find Full Text PDF[What electroneuromyographic criteria are required for the diagnosis of amyotrophic lateral sclerosis?].
Rev Neurol (Paris)
June 2006
Centre SLA, Service de Neurologie et d'Explorations Fonctionnelles Neurologiques, Hôpital Rangueil, CHU Toulouse.
Electroneuromyography is essential for the diagnostic of amyotrophic lateral sclerosis. The aim of conventional needle examen is to detect peripheral motoneuron involvement by the identification of active and chronic diffuse neurogenic activities. This brings up the problem of the selection of the muscle to test to enhance the sensitivity of the exam.
View Article and Find Full Text PDF[Electroneuromyographic criteria of amyotrophic lateral sclerosis].
Rev Neurol (Paris)
June 2006
Service de Neurologie et Maladies Neuromusculaires, Hôpital Universitaire de La Timone, Marseille.
Electrophysiological study plays a key role in the diagnosis of amyotrophic lateral sclerosis (ALS). ENMG demonstrates lower motor neuron involvement in muscles clinically involved but also in non clinically involved territories. Conventional EMG shows mixed signs of active denervation, partial chronic denervation and fasciculation, in a variable pattern from one muscle to another.
View Article and Find Full Text PDFClinical and electroneuromyographic studies of 1771 patients with diseases of the nervous and neuromuscular systems revealed disruption of the trophic supply to the skeletal muscles in cases of damage to both the segmento-peripheral neuromotor apparatus and vegetative and somatic segmental and suprasegmental formations. Electroneuromyographic indicators of the amyotrophic process include a decrease in the amplitude of the maximal M-response and a reduced number of functional motor units. In hyperkinetic syndromes, a paradoxical elevation of these indices is observed, which seems to be associated with "an alleviating trophotropic effect" exerted by striatal system impairment.
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