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Concurrent Surgical Care in an Austere Military Setting: A Preparation for Mass Casualty Events.
Mil Med
January 2025
Navy Medicine Readiness and Training Command, 620 John Paul Jones Cir, Portsmouth, VA 23708, USA.
Background: The U.S. military utilizes small, forward deployed surgical teams to provide Role 2 surgical care in austere environments.
View Article and Find Full Text PDFMultisport-Integrated Training for Rugby Instructors: Success and Effects on Minirugby Players.
J Funct Morphol Kinesiol
December 2024
Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.
Background/objectives: The educational system thinking approach (ST) takes a holistic vision of instructors/teachers and learners' relationships, making sports pivotal for reflection on education. This study evaluated the efficacy of a multisport ST-based course on minirugby instructors' teaching competence and children players' motor conduct.
Methods: The twenty-five rugby instructors (IAC) attended the 25 h course and the children of their teams (n = 109, Ch-IAC) participated in this study as experimental groups.
Engineering a high-throughput clone for industrial-scale production of long-acting GLP-1 analogue with retained bio-efficacy.
Biotechnol Prog
January 2025
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Type 2 diabetes mellitus (T2DM) and obesity are critical global health issues with rising incidence rates. Glucagon-like peptide-1 (GLP-1) analogues have emerged as effective treatments due to their ability to regulate blood glucose levels and gastric emptying through central nervous signals involving hypothalamic receptors, such as leptin. To address the short plasma half-life of native GLP-1, a C-16 fatty acid was conjugated to lysine in the GLP-1 analogue sequence to enhance its longevity.
View Article and Find Full Text PDFUnveiling the critical roles of cellular metabolism suppression in antibiotic tolerance.
NPJ Antimicrob Resist
June 2024
William Brookshire Chemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.
Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria, potentially acting as antagonists by inducing cell dormancy and promoting cell survival. However, the specific synergistic or antagonistic effects of these inhibitors depend on factors like their mechanisms of action, concentrations, and treatment timings, which require further investigation. In our study, we systematically explored the synergistic interactions of various metabolic inhibitors-such as chloramphenicol (a translation inhibitor), rifampicin (a transcription inhibitor), arsenate (an ATP production inhibitor), and thioridazine (a PMF inhibitor)-in combination with ofloxacin.
View Article and Find Full Text PDFCirc_0114428 knockdown inhibits ROCK2 expression to assuage lipopolysaccharide-induced human pulmonary alveolar epithelial cell injury through miR-574-5p.
J Physiol Sci
January 2025
Department of Critical Care Medicine, The Third People's Hospital of Qingdao, No. 29 Yongping Road, Licang District, 266000, Qingdao, Shandong, China. Electronic address:
Background: Sepsis-induced acute lung injury (ALI) accounts for about 40% of ALI, accompanied by alveolar epithelial injury. The study aimed to reveal the role of circular RNA_0114428 (circ_0114428) in sepsis-induced ALI.
Methods: Human pulmonary alveolar epithelial cells (HPAEpiCs) were treated with lipopolysaccharide (LPS) to mimic a sepsis-induced ALI cell model.
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