Central anticholinergic effects of N-ethyl-2-pyrrolidylmethyl-cyclopentylphenyl glycollate.

The following effects of N-ethyl-2-pyrrolidyl-methyl-cyclopentylphenyl glycollate (PMCG) have been studied: effects on aggressive behaviour in mice and on general behaviour in rats, protective effects against central action of arecoline and nicotine in mice, thermo-regulatory effects in mice, protective action in poisonings with fluostigmine in mice and rats, and effects on bioelectrical activity of the brain in cats. It was stated that PMCG possesses a strong central anticholinergic activity blocking predominantly central muscarinic receptors; PMCG had also strong protective effects in anticholinesterase intoxications. It is suggested that this drug could have antiemotional and antiparkinsonian properties.