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"Association of vitamin D blood deficiency and the rs731236 polymorphism vitamin D receptor with primary knee osteoarthritis in subjects from Mexico".
Clin Rheumatol
January 2025
Department of Molecular Biology, Institute of Genomic Science and Medicine, Juárez Avenue 1822 Oriente, 27000, Torreón, Coahuila, México.
Vitamin D deficiency is a public health problem worldwide. Some studies have associated serum vitamin D deficiency with knee osteoarthritis. Additionally, some vitamin D receptor polymorphisms have been linked to knee osteoarthritis.
View Article and Find Full Text PDFStates Do Not Delineate the "Accepted Medical Standards" for Brain Death/Death by Neurologic Criteria Determination.
Neurocrit Care
January 2025
Division of Neurocritical Care, Departments of Neurology and Neurosurgery, New York University Langone Medical Center, 530 First Avenue, MSB-2-206, New York, NY, 10016, USA.
Background: The Uniform Determination of Death Act requires brain death/death by neurologic criteria (BD/DNC) determination to be in accordance with "accepted medical standards." The medical organizations responsible for delineating these guidelines are only specified statutorily in two states. State health organizations (SHOs) are composed of policy experts and medical professionals who are responsible for addressing medical, ethical, and legislative problems related to health.
View Article and Find Full Text PDFProbing the properties of PTEN specific botulinum toxin type E mutants.
J Neural Transm (Vienna)
January 2025
Institut für Zellbiochemie, OE 4310, Medizinische Hochschule Hannover, 30623, Hannover, Germany.
Botulinum neurotoxins (BoNT) are established biopharmaceuticals for neuromuscular and secretory conditions based on their ability to block neurotransmitter release from neurons by proteolyzing specific soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Recently, a mutant catalytic domain of serotype E (LC/E) exhibiting 16 mutations was reported to cleave the phosphatase and tensin homolog (PTEN). This molecule represents an attractive new target in neurons as several reports support PTEN knockdown as a strategy to stimulate axonal regeneration after injury.
View Article and Find Full Text PDFDesign features of the rotating head total hip arthroplasty by Weber-Huggler- a forgotten technical solution to reduce wear.
Arch Orthop Trauma Surg
January 2025
Division of Orthopaedics and Traumatology, Cantonal Hospital Winterthur, Winterthur, Switzerland.
Total hip arthroplasty (THA) is a very successful operation. Once the problem of implant fixation was solved with the use of bone cement, the next development steps focused on improving the bearing. Weber, a Swiss surgeon, introduced the first modular heads in THA.
View Article and Find Full Text PDFLLMs, Truth, and Democracy: An Overview of Risks.
Sci Eng Ethics
January 2025
Department of Philosophy, University of Vienna, Vienna, Austria.
While there are many public concerns about the impact of AI on truth and knowledge, especially when it comes to the widespread use of LLMs, there is not much systematic philosophical analysis of these problems and their political implications. This paper aims to assist this effort by providing an overview of some truth-related risks in which LLMs may play a role, including risks concerning hallucination and misinformation, epistemic agency and epistemic bubbles, bullshit and relativism, and epistemic anachronism and epistemic incest, and by offering arguments for why these problems are not only epistemic issues but also raise problems for democracy since they undermine its epistemic basis- especially if we assume democracy theories that go beyond minimalist views. I end with a short reflection on what can be done about these political-epistemic risks, pointing to education as one of the sites for change.
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