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Inhibition of Sodium/Hydrogen Exchanger-1 in the Right Ventricle and Lung Dysfunction Induced by Experimental Pulmonary Arterial Hypertension in Rats.
J Am Heart Assoc
March 2025
Unité de Cardiologie Pédiatrique University Hospital of Geneva, University of Geneva Switzerland.
Background: Life-threatening pulmonary arterial hypertension (PAH) still lacks a direct therapeutic approach targeted to the molecular defects associated with the disease. Here, we focus on the impaired regulation of intracellular acidity and sodium/calcium overload by testing the hypothesis that inhibiting NHE-1 (sodium/hydrogen exchanger isoform 1) with rimeporide enables the recovery of pulmonary and right ventricular dysfunctions in the Sugen5416/hypoxia PAH model in rats.
Methods And Results: Adult Sprague-Dawley male rats (n=44) rats were divided into 2 broad groups: control and Sugen5416/hypoxia.
Development of ultrasonic-assisted gelatin-based biodegradable packaging film incorporated with turmeric extract for the shelf-life extension of chicken minced meat.
Int J Biol Macromol
March 2025
Department of Food Science, Government College University Faisalabad, Pakistan. Electronic address:
This study aims to develop the gelatin-based packaging film incorporated with turmeric extract to enhance the shelf life of a minced chicken. The films were subjected to functional, morphological and physicochemical characterization. The results showed that ethanolic extract of turmeric has a higher amount of turmerone and ar-turmerone along with some other bioactive compounds.
View Article and Find Full Text PDFFirst articulating os coxae, femur, and tibia of a small adult Paranthropus robustus from Member 1 (Hanging Remnant) of the Swartkrans Formation, South Africa.
J Hum Evol
March 2025
Evolutionary Studies Institute, University of the Witwatersrand, Johannesburg, WITS 2050, South Africa; Department of Biology, University of Alabama at Birmingham, Birmingham, AL, 35205, USA.
Since paleontological work began there in 1948, Swartkrans (South Africa) has yielded hundreds of Early Pleistocene hominin fossils, currently attributed to (in ascending order of quantity) cf. Australopithecus africanus, Homo spp., and Paranthropus robustus.
View Article and Find Full Text PDFChlorogenic Acid as a Neuroprotective Agent: Enhancing Plasticity and Promoting Brain Health and Functional Reserve.
CNS Neurol Disord Drug Targets
February 2025
Instituto de Fisiología, Benemerita Universidad Autónoma de Puebla, 14 Sur 6301, San Manuel CU, CP 72570, Puebla, México.
Introduction: Functional reserve, the process that warrants the brain to have resources to maintain key functions and processes when facing neurodegeneration, may be strengthened in nominally healthy subjects by measures that prompt neural plasticity throughout life.
Method: In this work, we administered Chlorogenic Acid (CGA) to evaluate its ability to promote functional morphological plasticity in the frontal cortical-striatal circuit of healthy mice, a pathway exposed constantly to oxidative challenges, excitotoxicity, and neuroinflammation. The magnitude of neural plasticity was estimated by assessing spontaneous motor behavior (open field), the relative magnitude of neuronal activation (number of c-Fos positive neurons), dendritic remodeling (Golgi- Cox impregnation), the availability of Brain-Derived Neurotrophic Factor (BDNF) (semiquantitative Western blotting), and lipid peroxidation (TBARS assay) in CGA- or vehicle-administered C57BL/6 male mice.
Establishment of an Acute Karoshi Rat Model and Its Metabolic, Functional and Morphological Changes.
Fa Yi Xue Za Zhi
October 2024
Medicolegal Department of Shantou University Medical College, Judicial Expertise Center of Shantou University, Shantou 515041, Guangdong Province, China.
Objectives: To investigate the occurrence and mechanism of acute Karoshi and explore its forensic identification.
Methods: SD rats were divided into the control group (=15) and experimental groups (=45, acute Karoshi group and overwork survival group). A severe fatigue model was established by combining forced swimming under load to exhaustion and sleep deprivation.
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