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Brazilian honey: Metabolomic analysis and characterization by 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy and chemometrics.
Food Res Int
April 2025
UFSC, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Honey is a complex matrix that contains a wide range of compounds. This rich composition is influenced by diverse environmental factors, including geographic and botanical origin. Honey has been among the most commonly tampered foods worldwide, with improvements in techniques to do it.
View Article and Find Full Text PDFAlzheimer's disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting tau phosphorylation, a key factor in Alzheimer's disease progression. It comprehensively summarizes current research on various natural compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, and terpenoids, highlighting their multitarget mechanisms, such as modulating kinases and phosphatases.
View Article and Find Full Text PDFDatura stramonium - A Dangerous Weed and Alternative Drug of Abuse: An Overview of Poisoning Cases in 21st Century.
Planta Med
March 2025
Department of Alternative and Vegetable Crops, Institute of Field and Vegetable Crops, Novi Sad, Serbia.
is a well-known cosmopolitan weed known by several common names: thorn apple (due to the appearance of its fruits), Angel's trumpet (linked to its flowers), loco seed (referring to the hallucinogenic properties of its seeds), jimson weed (originating from the first recorded poisoning involving this plant), and apple of Peru (indicating the plant's origin). All parts of the plant contain the tropane alkaloids hyoscyamine, scopolamine, and atropine together with several minor alkaloids, which cause poisoning such as typical anticholinergic syndrome with neuropsychiatric effects. A review of 114 papers from various databases (Scopus, Web of Science, PubMed, and Google Scholar) revealed that poisoning incidents involving this plant have been relatively common from 2001 to 2024.
View Article and Find Full Text PDFPenile diffuse large B-cell lymphoma in a young man.
BMJ Case Rep
March 2025
Hematology/Oncology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Here, we present the case of a young man active-duty service member diagnosed with stage IE penile diffuse large B-cell lymphoma (DLBCL), germinal centre B-cell (GCB) subtype. Primary penile DLBCL is an exceptionally rare condition, with fewer than 30 cases reported in the medical literature. Notably, this patient is significantly younger than the typical demographic, as extranodal DLBCL affecting the penis usually occurs in elderly men, with a median age of 69 years at diagnosis.
View Article and Find Full Text PDFHaemophagocytic lymphohistiocytosis (HLH) is a condition of uncontrolled immune activation caused by genetic defects or triggered by infections, malignancies, autoimmune diseases, drugs, pregnancy or post-transplant immunosuppression. This case describes a young man presenting with clinical jaundice and abnormal blood tests, including raised inflammatory markers, abnormal liver function, low haemoglobin (65 g/L) and a low white blood cell count (3.08×10/L).
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