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Recombinant Abelson Tyrosine Protein Kinase (rAbl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells.
Animals (Basel)
January 2025
Guangxi Colleges and Universities Key Laboratory of Prevention and Control for Animal Disease, College of Animal Science and Technology, Guangxi University, Nanning 530005, China.
can modulate host immune mechanisms through excretory-secretory products (ESP). As one of the components of ESP, it is unknown whether Abelson tyrosine protein kinase (Abl) is involved in parasite-host immune interaction. To investigate the immunoregulatory function of Abl in , we cloned and expressed the gigantica Abl protein and assessed its effect on specific immune functions of buffalo peripheral blood mononuclear cells (PBMCs).
View Article and Find Full Text PDFConventional and Advanced Methods Used for the Diagnosis of Fascioliosis, a Food-Borne Zoonotic Disease.
J Parasitol Res
January 2025
Department of Parasitology, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Fascioliosis is a food-borne zoonotic helminth infection caused by flatworms belonging to the family Fasciolidae, primarily affecting ruminants. The chronic form of fascioliosis is the most prevalent and is characterized by anemia, weight loss, cirrhosis, and liver dysfunction, along with atrophy, jaundice, and bottle jaw. In humans, infection results in fever, nausea, skin rashes, and severe abdominal pain.
View Article and Find Full Text PDFUnraveling the microRNAs Involved in Fasciolosis: Master Regulators of the Host-Parasite Crosstalk.
Int J Mol Sci
December 2024
Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología, UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Universidad de Córdoba, Campus de Rabanales, Edificio Sanidad Animal, 14071 Córdoba, Spain.
Fasciolosis is a neglected tropical disease caused by helminth parasites of the genus spp., including () and (), being a major zoonotic problem of human and animal health. Its control with antihelminthics is becoming ineffective due to the increase in parasite resistance.
View Article and Find Full Text PDFDetailed characterisation of the Co-Smad protein in liver fluke .
J Helminthol
January 2025
Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Fasciolosis, caused by the liver flukes and , is a zoonotic parasitic disease associated with substantial economic losses in livestock. The transforming growth factor-beta signalling pathway is implicated in developmental processes and biological functions throughout the animal kingdom, including the spp. It may also mediate host-helminth interactions during infection.
View Article and Find Full Text PDFPotency of anti-trematode in inhibiting cathepsin-2L and cathepsin-5L of using homology, docking, and molecular dynamics.
Open Vet J
November 2024
Parasitology Department, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Background: Cathepsin-L (FhCL) is a group of enzymes that most flukes express and secreted significantly in parasite-host interactions. Researches are focusing on antigens released by as one of the keys to understanding immunologic pathways in parasite infection and targets for anthelmintics. Efforts to suppress FhCL function through vaccination or therapy using anthelmintic drugs are key factors in controlling field-level trematode infections.
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