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Extended-spectrum beta-lactamase and carbapenemase-producing Gram-negative bacteria in urinary tract infections in Ethiopia: a systematic review and meta-analysis.
BMC Urol
January 2025
Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Urinary tract infection (UTI) is one of the most common infections worldwide, particularly in developing countries. It also is among the most prevalent nosocomial infections, largely due to the widespread use of urinary catheters in hospitalized patients. These catheters often act as reservoirs for multidrug-resistant bacteria, including extended-spectrum beta-lactamase- and carbapenemase-producing pathogens, which significantly limit treatment options and delay appropriate care.
View Article and Find Full Text PDFOral health promotion: a qualitative study to explore perspectives of kindergarten nurses at Qatar.
BMC Oral Health
January 2025
Qatar University, College of Dental Medicine, Doha, Qatar.
Background: The oral health of preschool children remains a concern globally. Kindergarten and school nurses can improve oral health by reducing the incidence of Early Childhood Caries (ECC) among children. This study aimed to explore the perceptions of kindergarten nurses about a proposed oral health promotion program to be implemented in primary health centres and kindergartens.
View Article and Find Full Text PDFAnomalous entropy-driven kinetics of dislocation nucleation.
Nat Commun
January 2025
Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.
The kinetics of dislocation reactions, such as dislocation multiplication, controls the plastic deformation in crystals beyond their elastic limit, therefore critical mechanisms in a number of applications in materials science. We present a series of large-scale molecular dynamics simulations that shows that one such type of reactions, the nucleation of dislocation at free surfaces, exhibit unconventional kinetics, including unexpectedly large nucleation rates under compression, very strong entropic stabilization under tension, as well as strong non-Arrhenius behavior. These unusual kinetics are quantitatively rationalized using a variational transition state theory approach coupled with an efficient numerical scheme for the estimation of vibrational entropy changes.
View Article and Find Full Text PDFCombining T cell receptor sequencing and transcriptomics to characterize tissue-resident T cells from human gut biopsies.
Biochem Biophys Res Commun
January 2025
Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:
Gastrointestinal T cells (GI-T) play a critical role in mucosal immunity, balancing tolerance and pathogen defence. T cells recognize antigens via T cell receptors (TCRs). Next-generation sequencing (NGS) is utilized to analyse TCR repertoires in contexts such as health, haematological diseases, autoimmunity, and inflammation.
View Article and Find Full Text PDFIncompatible Aedes aegypti male releases as an intervention to reduce mosquito population-A field trial in Puerto Rico.
PLoS Negl Trop Dis
January 2025
Division of Vector Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico.
Mosquito-transmitted viruses such as dengue are a global and growing public health challenge. Without widely available vaccines, mosquito control is the primary tool for fighting the spread of these viruses. New mosquito control technologies are needed to complement existing methods, given current challenges with scalability, acceptability, and effectiveness.
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