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Relation between dimensional distinctiveness and comparison format in a novel noun generalization task in preschoolers.
Front Psychol
January 2025
LEAD, CNRS, UMR 5022, Université Bourgogne Europe, Dijon, France.
Numerous studies have shown that in novel noun generalization tasks, the simultaneous presentation of multiple learning examples increases the percentage of generalizations that are based on less salient properties, compared to the presentation of a single learning example. In this research with preschoolers ( = 300) we demonstrate that this effect can be modulated by dimensional distinctiveness, i.e.
View Article and Find Full Text PDFThe emergence of East Asian spring ephemerals and the unique ecosystem can be attributed primarily to vicariance, brought about by the Quaternary rifting of the Okinawa Trough, the formation of the East China Sea, and the isolation of the island chains of Ryukyu, Japan, and Taiwan from the Asian continent. The northern forests of Japan, dominated by and the associated , present a captivating display of spring-flowering ephemerals, including , , , and . Among these, is also considered part of the spring ephemerals.
View Article and Find Full Text PDFDevelopment of right ventricular electromechanical dyssynchrony following surgical repair of tetralogy of Fallot in infants.
Front Pediatr
January 2025
Division of Pediatric Cardiology, Division of Pediatrics, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, MO, United States.
Background: In adolescents and adults with tetralogy of Fallot (TOF), right ventricle (RV) electromechanical dyssynchrony (EMD) due to right bundle branch block (RBBB) is associated with reduced exercise capacity and RV dysfunction. While the development of RBBB following surgical repair of tetralogy of Fallot (rTOF) is a frequent sequela, it is not known whether EMD is present in every patient immediately following rTOF. The specific timing of the onset of RBBB following rTOF therefore provides an opportunity to assess whether acute RBBB is associated with the simultaneous acquisition of EMD.
View Article and Find Full Text PDFAmphotericin B tissue penetration and pharmacokinetics in healthy and -infected rats: insights from microdialysis and population modeling.
Front Pharmacol
January 2025
Center for Pharmacometrics and System Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States.
Introduction: This study evaluated the relationship between total plasma and free kidney concentrations of amphotericin B (AmB) in healthy and -infected Wistar rats using microdialysis and has the potential to significantly impact future research in this field and promote the development of antifungal drugs. The findings of this study, which show that plasma levels are a good predictor for AmB kidney concentrations and can be used to optimize its dosing regimen, underscore the importance of this research.
Methods: Microdialysis probe recovery rates were determined by dialysis and retrodialysis , as well as by retrodialysis .
Characterization of tumor epigenetic aberrations is integral to understanding the mechanisms of tumorigenesis and provide diagnostic, prognostic, and predictive information of high clinical relevance. Among the different tumor-associated epigenetic signatures, 5 methyl-cytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two most well-characterized DNA methylation alterations linked to cancer pathogenesis. 5hmC has a tissue-specific distribution and its abundance is subjected to changes in tumor DNA, making it a promising biomarker.
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