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Alkylated DNA repair by a novel HhH-GPD family protein from Crenarchaea.
Nucleic Acids Res
January 2025
College of Plant Protection, Agricultural University of Hebei, No. 2596 Lekai South Street, Baoding City, Lianchi District, Hebei Province 071001, China.
HhH-GPD (helix-hairpin-helix-glycine/proline/aspartate) family proteins are involved in DNA damage repair. Currently, mechanism of alkylated DNA repair in Crenarchaea has not been fully clarified. The hyperthermophilic model crenarchaeon Saccharolobus islandicus REY15A possesses a novel HhH-GPD family protein (Sis-HhH-GPD), where its Ser152 corresponds to a conserved catalytic Asp in other HhH-GPD homologs.
View Article and Find Full Text PDFA novel chitosan-Schiff bases bearing a new quinoxaline moiety as an approach for potent antimicrobial agent: Synthesis, characterization and in vitro assessments.
Carbohydr Polym
March 2025
Department of Chemistry, Faculty of Science (boys), Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
This study aims to enhance the antimicrobial properties of chitosan through preparing novel chitosan Schiff bases via coupling with 4-formylphenyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonate (B5) where, different molar ratios of B5 were used to prepare various Schiff bases with chitosan, resulting in Schiff bases coded as d5, d6, d7, and d8, respectively. The modified chitosan samples (d5, d6, d7, and d8) showed reduced crystallinity and improved thermal stability. The crystallinity index of unmodified chitosan was 64 %, which decreased to 59, 55.
View Article and Find Full Text PDFContrastive independent subspace analysis network for multi-view spatial information extraction.
Neural Netw
January 2025
College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, Guangdong, China.
Multi-view classification integrates features from different views to optimize classification performance. Most of the existing works typically utilize semantic information to achieve view fusion but neglect the spatial information of data itself, which accommodates data representation with correlation information and is proven to be an essential aspect. Thus robust independent subspace analysis network, optimized by sparse and soft orthogonal optimization, is first proposed to extract the latent spatial information of multi-view data with subspace bases.
View Article and Find Full Text PDFNucleic acid joining enzymes: biological functions and synthetic applications beyond DNA.
Biochem J
January 2025
School of Science, University of Waikato, Hamilton, Waikato, 3216, New Zealand.
DNA-joining by ligase and polymerase enzymes has provided the foundational tools for generating recombinant DNA and enabled the assembly of gene and genome-sized synthetic products. Xenobiotic nucleic acid (XNA) analogues of DNA and RNA with alternatives to the canonical bases, so-called 'unnatural' nucleobase pairs (UBP-XNAs), represent the next frontier of nucleic acid technologies, with applications as novel therapeutics and in engineering semi-synthetic biological organisms. To realise the full potential of UBP-XNAs, researchers require a suite of compatible enzymes for processing nucleic acids on a par with those already available for manipulating canonical DNA.
View Article and Find Full Text PDFTaming large-scale genomic analyses via sparsified genomics.
Nat Commun
January 2025
Department of Information Technology and Electrical Engineering, ETH Zürich, Zurich, Switzerland.
Searching for similar genomic sequences is an essential and fundamental step in biomedical research. State-of-the-art computational methods performing such comparisons fail to cope with the exponential growth of genomic sequencing data. We introduce the concept of sparsified genomics where we systematically exclude a large number of bases from genomic sequences and enable faster and memory-efficient processing of the sparsified, shorter genomic sequences, while providing comparable accuracy to processing non-sparsified sequences.
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