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The potential link between the development of Alzheimer's disease and osteoporosis.
Biogerontology
January 2025
Department of Physiology, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Alzheimer's disease (AD) and osteoporosis (OP) pose distinct but interconnected health challenges, both significantly impacting the aging population. AD, a neurodegenerative disorder characterized by memory impairment and cognitive decline, is primarily associated with the accumulation of abnormally folded amyloid beta (Aβ) peptides and neurofibrillary tangles in the brain. OP, a skeletal disorder marked by low bone mineral density, involves dysregulation of bone remodeling and is associated with an increased risk of fractures.
View Article and Find Full Text PDFAdvances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis.
Drug Des Devel Ther
January 2025
Hubei Selenium and Human Health Institute, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, 445000, People's Republic of China.
Selenium (Se), a critically essential trace element, plays a crucial role in diverse physiological processes within the human body, such as oxidative stress response, inflammation regulation, apoptosis, and lipid metabolism. Organ fibrosis, a pathological condition caused by various factors, has become a significant global health issue. Numerous studies have demonstrated the substantial impact of Se on fibrotic diseases.
View Article and Find Full Text PDFVasant Kusumakar Rasa Ameliorates Diabetic Encephalopathy by Reducing Oxidative Stress and Neuroinflammation and Improving Neurotransmitter Levels in Experimental Animals.
Cureus
December 2024
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed to be University, Mumbai, IND.
Purpose: Diabetic encephalopathy (DE) is one of the complications of diabetes that affects the brain. In the Ayurveda system of medicine, Vasant Kusumakar Rasa (VKR) is cited as a classical herbo-mineral formulation for diabetes. However, the role of VKR in DE is still unclear.
View Article and Find Full Text PDFEffect of precise health management combined with physical rehabilitation on bone biomarkers in senile osteoporosis patients.
Sci Rep
January 2025
Health Management Center, The First Hospital of Hebei Medical University, No.89 Donggang Road, Yuhua District, Shijiazhuang, 050000, Hebei Province, China.
This study delves into the impact of precise health management coupled with physical rehabilitation on bone biomarkers in elderly patients with osteoporosis. Two hundred and forty individuals diagnosed with senile osteoporosis were randomly assigned to either the observation group (precision health management group, n = 120) or the control group (routine health management group, n = 120). Patients in the control group received standard health care, while those in the observation group received personalized health care along with physical therapy.
View Article and Find Full Text PDFEnhancing hepatocellular carcinoma therapy with DOX-loaded SiO nanoparticles via mTOR-TFEB pathway autophagic flux inhibition.
J Nanobiotechnology
January 2025
Imaging Center, The Third Affiliated Hospital of Anhui Medical University, Hefei, 230061, China.
Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. To enhance the biosafety and reduce the side effects of these drugs, various nanocarrier delivery systems have been developed. In this study, we loaded the anticancer drug doxorubicin (DOX) and an MRI contrast agent into silica nanoparticles, coating them with pH-responsive and tumor cell-targeting polymers.
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