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[Mechanism of Huachansu Injection against colorectal cancer based on network pharmacology and cellular experimental].
Zhongguo Zhong Yao Za Zhi
September 2024
Shanghai Ocean University Shanghai 201306, China Shanghai Sixth People's Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University Shanghai 200030, China.
Article Synopsis
- The study investigated the anti-cancer effects of Huachansu Injection (HCSI) on colorectal cancer (CRC) using various methods, including network pharmacology and cellular experiments.
- Researchers identified and analyzed 16 bufadienolides in HCSI, selecting ten with significant content to target CRC-related proteins and pathways, particularly focusing on the PI3K/Akt/mTOR signaling pathway.
- Experimental findings showed that HCSI and its active components inhibited cancer cell growth and migration while promoting cell death, offering insights into their potential therapeutic use against CRC.
Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na(+)/K(+)-ATPase activity.
Toxicon
February 2016
Laboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, CCS Bloco J, Ilha do Fundão, 21941-902, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Parotoid gland secretions of toad species are a vast reservoir of bioactive molecules with a wide range of biological properties. Herein, for the first time, it is described the isolation by preparative reversed-phase HPLC and the structure elucidation by NMR spectroscopy and/or mass spectrometry of nine major bufadienolides from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger: ψ-bufarenogin, gamabufotalin, bufarenogin, arenobufagin, 3-(N-suberoylargininyl) marinobufagin, bufotalinin, telocinobufagin, marinobufagin and bufalin. In addition, the secretion was analyzed by UPLC-MS/MS which also allowed the identification of azelayl arginine.
View Article and Find Full Text PDFψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling.
Oncotarget
May 2015
The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
Resistance of hepatocellular carcinoma (HCC) to existing chemotherapeutic agents largely contributes to the poor prognosis of patients, and discovery of novel anti-HCC drug is in an urgent need. Herein we report ψ-Bufarenogin, a novel active compound that we isolated from the extract of toad skin, exhibited potent therapeutic effect in xenografted human hepatoma without notable side effects. In vitro, ψ-Bufarenogin suppressed HCC cells proliferation through impeding cell cycle progression, and it facilitated cell apoptosis by downregulating Mcl-1 expression.
View Article and Find Full Text PDFCinobufacino injection is purified from water extraction of the skin of Bufo bufo gargarizans, which has been widely used for various cancers in clinic with significant anti-tumor effects. Bufadienolides were regarded as the main active constituents of cinobufacino injection in previous reports. In present study, 6 bufadienolides were isolated and purified from Cinobufacino injection.
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